Scientist – RNA Sequencing / ddPCR
Thermo Fisher Scientific · Boston, MA · 3 days ago
On-siteScience$35–$43/hrFull-time
About the role
This is a full-time, Monday-Friday, 8am-5pm EST position based at a customer's site in (insert location – i.e. Boston, MA).
Responsibilities
- Independently design, execute, troubleshoot, optimize, and interpret analytical method development experiments using digital PCR, qPCR, ddPCR, bulk RNA sequencing, NanoString nCounter, Oxford Nanopore sequencing.
- Perform DNA/RNA extraction, sequencing library preparation, sequencer operation, digital PCR workflows, and other associated laboratory procedures with a high standard of technical rigor.
- Design and conduct experiments to evaluate assay performance characteristics, including accuracy, precision, linearity, sensitivity, and technology comparisons.
- Analyze and interpret data using R, GraphPad Prism, JMP, and related bioinformatics tools to support assay development, process characterization, and technology evaluation.
- Organize, analyze, and summarize data for project updates, technical reports, study summaries, and internal presentations.
- Author and review protocols, SOPs, technical reports, study documentation, and regulatory support documents.
- Collaborate cross-functionally with partners in analytical development, process development, research, and other teams to support analytical strategy and project goals.
- Operate, maintain, and troubleshoot laboratory instrumentation, including NextSeq 2000, NovaSeq X, PromethION 24, NanoString nCounter Prep Station/Digital Analyzer, and digital PCR platforms.
- Maintain laboratory organization, instrument readiness, reagent inventory, and compliance with documentation and laboratory best practices.
Requirements
- Bachelor's degree in lab sciences such as Chemistry, Biochemistry, Material Science, Immunology, Biology, Molecular Biology or similar.
- Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 2+ years') OR Master's degree.
Qualifications
- Digital PCR (ddPCR, dPCR)
- qPCR
- NanoString nCounter (NICE TO HAVE)
- Bulk RNA-sequencing library preparation and sequencing
- DNA/RNA extraction
- Oxford Nanopore library preparation and sequencing workflows
- Statistical analysis and data visualization using R, GraphPad Prism, JMP, and Microsoft Excel
- Differential gene expression analysis using DESeq2
- Pathway enrichment analysis using GSEA and Gene Ontology
- Sequencing data quality control, interpretation, and reporting
- Analysis of digital PCR and sequencing datasets to support method development and process characterization
- Proficiency with Microsoft PowerPoint, Excel, and Word
Skills
- Communication
- Physical ability to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.
- Physical ability to work upright and stationary and/or standing for typical working hours.
- Physical ability to lift and move objects up to 25 pounds.
- Physical ability to work in non-traditional work environments.
- Ability to use and learn standard office equipment and technology with proficiency.
- May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments.
- Ability to perform successfully under pressure while prioritizing and handling multiple projects or activities.
Benefits
- Competitive remuneration
- Annual incentive plan bonus
- Healthcare
- A range of employee benefits
- Comprehensive Total Rewards package
- A choice of national medical and dental plans, and a national vision plan, including health incentive programs
- Employee assistance and family support programs, including commuter benefits and tuition reimbursement
- At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
- Retail and savings programs, such as our competitive 401(k) U.S. retirement savings plan
- Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
Pay
The hourly pay range estimated for this position based in Massachusetts is $35.00–$43.00.
Schedule
Full-time, Monday-Friday, 8am-5pm EST.