Advisor - RNA Chemistry

Responsibilities

• Design and synthesize oligonucleotides and novel nucleotide analogs for incorporation into siRNA and ASO platforms to support portfolio drug discovery efforts
• Independently identify critical scientific questions and develop well-reasoned chemistry strategies for enhancing the potency, safety, and durability of oligonucleotide drug molecules
• Collaborate with in vitro and in vivo biologists to evaluate new biological targets of interest, integrating cross-functional information to support data-driven decisions
• Design and implement chemistry strategies for delivery of oligonucleotide medicines to tissues and cell types of interest, anticipating and managing risk to minimize impact on project timelines
• Develop and test new ideas and apply innovative solutions that significantly advance scientific and/or project understanding across multiple drug modalities, including oligonucleotides, antibody-oligonucleotide conjugates, and peptide-oligonucleotide conjugates
• Build a diverse cross-functional and external network to understand how different fields contribute to oligonucleotide research and development
• Define clear scientific hypotheses, goals, critical success factors, and timelines in support of advancing the portfolio
• Mentor and develop junior scientists, providing constructive feedback and encouraging a culture of excellence and knowledge sharing
• Represent genetic medicine project teams in presentations to departmental and cross-functional senior leadership teams

Qualifications

• Ph.D. in organic chemistry, or a related field with 0–5+ years of experience in the pharmaceutical industry or relevant postdoctoral training