Advisor - Genomic Sciences, RNA Therapeutics

About the role

We are seeking an experienced scientist to join the Genomic Sciences team in Lilly Genetic Medicine’s RNA Therapeutics organization. This team leverages high-throughput approaches to generate data that drives compound selection and lead optimization decisions and enables innovative cross-functional science both within RNA therapeutics and across therapeutic areas.

Responsibilities

• Design and execute NGS-based genomics experiments (e.g., 3’ RNA-seq, mRNA-seq, targeted panels, scRNA-seq, spatial transcriptomics, etc.) to support siRNA and ASO compound profiling, selectivity assessment, biodistribution studies, and mechanism-of-action characterization
• Independently identify scientific questions and develop experimental strategies that advance portfolio programs, applying an end-to-end understanding from assay design through data interpretation
• Establish and optimize functional genomics workflows at screening scale, including library preparation, multiplexing, QC, and sequencing across NGS platforms
• Integrate cross-functional and external information—transcriptomic, pharmacologic, structural—to support data-driven decision-making on compound progression and lead selection
• Leverage laboratory automation systems (e.g., Hamilton, Beckman) to increase throughput and reproducibility of genomics workflows
• Troubleshoot assay performance, diagnose failure modes, and implement corrective actions with minimal supervision
• Present scientific findings and recommendations to project teams, governance bodies, and external collaborators; contribute to publications, patents, and conference presentations
• Mentor junior scientists on experimental design, technical execution, and scientific rigor

Qualifications

• Ph.D. in genomics, molecular biology, genetics, or a related discipline with a minimum of 2 years of postdoctoral and/or industry experience