Scientist, In Vivo Biology

Responsibilities

• Design and execute innovative research strategies to identify causal regulators of cell state, aging, regeneration, and disease biology.
• Develop and apply robust experimental workflows connecting genetic perturbation to molecular and phenotypic readouts across cellular and animal models.
• Support genomic and molecular profiling methods, including transcriptome, proteome and single-cell readouts, to uncover novel biological mechanisms.
• Translate in vitro discoveries into in vivo systems through the design and execution of hands-on mouse studies in relevant disease models.
• Collaborate closely with computational scientists and cross-functional teams to integrate multidimensional datasets and generate actionable biological insight.
• Lead project strategy, experimental design, execution, troubleshooting, and data interpretation.
• Contribute to publications, patents, and broader scientific strategy.

Requirements

• PhD in Biology, Stem cell, Aging, Physiology, or related field, with relevant postdoctoral and/or industry experience preferred.
• Strong track record of scientific accomplishment through publications, patents, or impactful platform development.
• Demonstrated expertise in the following areas:
• Hands-on in vivo experience with disease mouse models.
• Disease cell and mechanistic biology.
• Ability to independently lead complex research projects from concept to execution.
• Strong analytical skills and ability to derive biological insight from multidimensional datasets.
• Excellent written and verbal communication skills.
• Demonstrated ability to work effectively in highly collaborative, interdisciplinary environments.
• Scientific rigor, creativity, and comfort operating in rapidly evolving areas.

Qualifications

• Experience in small rodent handling, with an ability to independently design and coordinate the execution of complex in vivo studies, including drug administration, tissue harvest and processing.
• Expertise in physiologically relevant mouse models for chronic diseases.
• Hands-on experience with in vivo delivery modalities such as AAV, LNP, or related delivery systems.
• Experience or interest in studying novel biological mechanisms and emerging areas of biology.

Preferred Qualifications

• Background in aging biology, regeneration, fibrosis, inflammation, metabolic disease, neurodegeneration, or related therapeutic areas.
• Direct experience with in vivo lung, kidney, or liver disease models.
• Hands-on experience generating and maintaining ex vivo precision-cut tissue slices.
• Experience with tissue-level genomics assays and analyses.

Pay

The salary range for San Diego Scientist I is $127,100 - $162,900, and for Scientist II is $143,800 - $184,300. Exact compensation may vary based on skills, experience, and location.