SCIENTIST III

Target pay range: $52–62/hour depending on experience. Contract role located on-site in Worcester, MA.

About the role

We are searching for a highly motivated Scientist to join our Analytical Development team at Bioresearch Center. The Analytical Characterization Group (ACG) within the Analytical Development Department focuses on providing routine, investigative, and in-depth characterization analyses of biologics to support product and process development for early-phase, late-phase, and commercial programs using liquid chromatography mass spectrometry (LC-MS), spectroscopy, and various other biophysical assays.

Responsibilities

• Perform mass spectrometry analyses (e.g., intact/reduced mass analysis by LC-MS and peptide mapping by LC-MS) of biologics to provide sequence verification and post-translational modification profiles.
• Independently perform separation methods (e.g., fractionation & analysis of variants) using HPLC and AKTA.
• Perform biophysical methods (e.g., DSC) of biologics to support characterization studies.
• Design and execute experiments for method development and/or investigations.
• Support process development by performing raw material analysis using vibrational spectroscopy and executing metabolomics experiments using mass spectrometry.
• Generate and communicate precise, reliable, and reproducible data in a timely manner.
• Organize and document experiments and results in an electronic laboratory notebook.
• Draft protocols, method development reports, and technical characterization reports.
• Maintain lab equipment.

Requirements

• Bachelor’s or Master’s in chemistry, biology, biochemistry, or related technical discipline with typically 5+ (BS) or 2+ (MS) years of relevant experience in a biotech/pharmaceutical industry setting.
• Hands-on experience with protein mass spectrometry, liquid chromatography, capillary electrophoresis, and protein biophysical characterization.
• Knowledge of HPLC or AKTA instrumentation.
• Fundamental understanding of protein structure, post-translational modifications, and analytical methods used for protein characterization.
• Working knowledge of bioinformatics tools to process and analyze mass spectrometry data is highly desirable.
• Knowledge of vibrational spectroscopy (e.g., IR, NIR, and Raman) and multivariate analysis is desirable.
• Proficient with Windows 10 and Microsoft Office (Outlook, Excel, Word, and PowerPoint).
• Excellent written communication, oral communication, organization, and multitasking skills.
• Hardworking and motivated to drive both efficiency and quality.
• Understand and adhere to corporate standards regarding code of conduct, safety, and appropriate handling of materials.