Scientist III

This position is located in Worcester, MA. It is a 4-month assignment with possibility for extension or conversion based on performance and budget.

Responsibilities

• Perform mass spectrometry analyses (i.e., intact/reduced mass analysis by LC-MS and peptide mapping by LC-MS) of biologics to provide sequence verification and post-translational modification profiles.
• Independently perform separation methods (e.g., fractionation & analysis of variants) using HPLC and AKTA.
• Perform biophysical methods (e.g., DSC) of biologics to support characterization studies.
• Design and execute experiments for method development and/or investigations.
• Support process development by performing raw material analysis using vibrational spectroscopy and executing metabolomics experiments using mass spectrometry.
• Generate and communicate precise, reliable, and reproducible data in a timely manner.
• Organize and document experiments and results in an electronic laboratory notebook.
• Draft protocols, method development reports, and technical characterization reports.
• Maintain lab equipment.

Requirements

• Bachelor’s or Master’s in chemistry, biology, biochemistry, or related technical discipline with typically 5+ (BS) or 2+ (MS) years of relevant experience in biotech/pharmaceutical industry setting.
• Hands-on experience with protein mass spectrometry, liquid chromatography, capillary electrophoresis, and protein biophysical characterization.
• Knowledge of HPLC or AKTA instrumentation.
• Fundamental understanding of protein structure, post-translational modifications, and analytical methods used for protein characterization.
• Working knowledge of bioinformatics tools to process and analyze mass spectrometry data is highly desirable.
• Knowledge of vibrational spectroscopy (e.g., IR, NIR, and Raman) and multivariate analysis is desirable.
• Proficient with Windows 10 and Microsoft Office (Outlook, Excel, Word, and PowerPoint).

Pay

$60–70/hour