Scientist II, Structural Biology

Responsibilities

• Plan and execute experiments with the aim of determining small molecule driven multi-protein complex structures by CryoEM and X-ray crystallography.
• Perform cryo-EM grid screening, optimization, data collection and refinement to enable high-quality structure determination.
• Interact with interdisciplinary teams (including chemists, computational chemists, biologists, project teams, and management) and clearly articulate structural data in a broader drug discovery context.
• Maintain excellent records and communication among internal and external colleagues.
• Be driven by a desire to be innovative in a high energy, fast paced environment and work collaboratively with a variety of colleagues across the organization.

Requirements

• PhD in structural biology or protein biochemistry or a related scientific discipline with 2-5 years of post-doctoral experience.
• Hands-on experience and expertise in cryo-EM sample optimization and grid preparation, data collection, map generation, and structure determination.
• Strong track record of solving challenging CryoEM problems such as preferred orientation, small proteins/complexes, modeling into low resolution maps, or iterative rounds of protein optimization.
• Hands on experise with modern software packages for data collection, refinement and visualization of structural biology data, and the ability to seamless switch between them based on need (e.g. CryoSPARC, RELION, Phenix, REFMAC, Coot, ChimeraX, Pymol).
• Excellent written, verbal communication, interpersonal and organization skills.
• Conscientious team-player interested in a fast-paced biotech environment.

Preferred Skills

• Hands-on experience and expertise in protein crystallization, crystal optimization and harvesting for data collection.
• Experience with biophysical characterization methods, including mass spectrometry, SEC-MALS, DLS, SPR, NMR and thermal shift assays.
• Experience with protein-protein complexes including antibodies/Fabs, molecular glues, PROTACs, etc.
• Experience working in a multidisciplinary team environment.
• Experience in gene construct design, expression and purification of recombinant proteins.

Benefits

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is $132,000 - $166,000 USD. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Schedule

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