Senior Scientist, Structural Biology

Responsibilities

• Lead experimental structural biology and protein biochemistry within the Institute of Medicine
• Develop and execute structural biology strategies (expression system, purification, structure determination method, etc.) to advance the Altos discovery portfolio from early target validation through lead optimization
• Collaborate with our in-house cryoEM core facility and CRO-based crystallographic facilities to deliver high-impact macromolecular structures
• Work collaboratively with cross-functional scientists to enable structure-based design on discovery programs across different modalities
• Represent structural biology and protein biochemistry on cross-functional project teams, and contribute to building and progressing the pipeline
• Manage external research activities conducted by CROs and collaborators
• Mentor and supervise junior scientists and technicians

Requirements

• PhD in Structural Biology, Biochemistry, Biophysics, or a related discipline
• 6+ years of experience in biotech or the pharmaceutical industry supporting structural biology efforts in large- or small-molecule drug discovery programs
• Proven track record of high-resolution structure determination using X-ray crystallography or cryoEM
• Strong publication record demonstrating expertise in structural biology
• Experience managing external CRO activities supporting protein production, X-ray crystallography, and cryoEM structure determination
• Strong leadership, collaboration, and communication skills

Qualifications

• Demonstrated expertise in protein engineering or structure-guided protein design
• Familiarity with structure-based drug design workflows and collaboration with medicinal/computational chemistry groups
• Experience developing strategy for structurally intractable targets
• Experience using structure prediction tools (e.g., AlphaFold, RosettaFold, Boltz) in an applied drug discovery setting
• Ability to communicate the nuances of protein biochemistry to non-specialist stakeholders and executive leadership, ensuring alignment on project milestones
• Experience in people management

Skills

Not specified

Benefits

Not specified

Pay

$172,400 - $221,000 Senior Scientist I, Structural Biology in Redwood City, CA. Exact compensation may vary based on skills, experience, and location.

Schedule

Not specified