Structural Biology Research Scientist

Responsibilities

• Design and generate expression constructs for viral proteins (e.g., envelope glycoproteins, capsid proteins, regulatory proteins).
• Develop and optimize expression systems (mammalian, insect, or stable cell lines).
• Purify proteins using chromatography methods (affinity, SEC, ion exchange).
• Perform binding and antigenicity assays (e.g., ELISA, BLI, SPR).
• Conduct biochemical and biophysical characterization (e.g., SEC-MALS, DLS).
• Prepare samples and optimize vitrification conditions for cryo-EM studies.
• Operate and/or coordinate use of cryo-EM instruments (e.g., Titan Krios, Glacios).
• Prepare technical reports, figures, and manuscripts.

  Requirements

  • PhD in Structural Biology or a related field.
  • Microsoft Office.
  • Technical experience needed to assist in studying the basic principles of plant and animal life.
  • Technical support and troubleshooting of sophisticated equipment.
  • At least 2 (two) years of experience.
  • Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must obtain approved adjudication of their public trust prior to onboarding with Guidehouse.
  • Candidates with an active public trust or suitability are preferred.

  Qualifications

  • Previous experience supporting NIH is a plus.

  Benefits

  • The annual salary range for this position is $85,000.00-$141,000.00.
  • Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package.

  Pay

  • The annual salary range for this position is $85,000.00-$141,000.00.

  Schedule

  • This is a full-time, on-site opportunity in Bethesda, MD.