Scientist II – Cell Line Development

About the role

Thermo Fisher Scientific Inc. is seeking a highly motivated individual with strong work behaviors to join our team as a Scientist II within our Cell Biology team. In this role, you will have the opportunity to contribute to research projects with the potential to make a significant impact in the scientific community.

Responsibilities

• Design experimental plans with guidance, execute studies, analyze experimental data, quantitative analyses and data summaries.
• Execute mammalian cell line development workflows, including transfection, stable pool generation, selection, single-cell cloning, clone screening, and data analysis.
• Develop and characterize recombinant mammalian cell lines for bioproduction, including assessment of growth, productivity, expression stability, and product quality.
• Work on complex problems of moderate scope where analysis of situations or data requires an in-depth evaluation of various factors.
• Troubleshoot and solve problems associated with various types of R&D projects.
• Exercise practical judgment within broadly defined practices and policies and exhibit creativity and foresight in selecting approaches and techniques for obtaining solutions.
• Interact closely with other internal departments (i.e., Marketing, Business Development, Quality, Operations) in commercializing new products and customer and business support.
• Maintain an accurate lab notebook to support the protection of intellectual property following relevant Thermo Fisher required standards.

Qualifications

• Master's degree in biology, Cell Biology, Molecular Biology, Biochemical Engineering, Biochemistry or other related field, or equivalent knowledge and relevant experience preferred; open to Bachelor's degree with 2 plus years of relevant experience.
• Expertise in the methods and techniques of mammalian cell culture and cell line development (i.e., shake flasks, deep well plates, single-cell cloning platforms, ambr15 micro-bioreactors, etc.).

Skills

• Proficiency in aseptic mammalian cell culture techniques, stable transfection, selection, single-cell cloning, and molecular biology methods.
• Solid understanding of data analysis and statistical software (e.g., JMP, GraphPad). Demonstrated ability to interpret complex datasets and make data-driven decisions.
• Excellent organizational, communication, and problem-solving skills. Ability to work both independently and collaboratively in a fast-paced environment.
• Competence in research design, cell line development troubleshooting, and evaluating new techniques and procedures.
• Demonstrated experience generating and characterizing stable recombinant mammalian cell lines, including evaluation of growth, productivity, and stability.
• Experience with cell line development platforms and clone isolation/screening technologies (e.g., limiting dilution, single-cell dispensing, FACS, or imaging-based systems) (preferred).
• Prior industrial experience, particularly in cell line development, upstream process development and/or cell culture media formulation development (preferred).
• Understanding of factors influencing mammalian cell growth, recombinant protein expression, productivity, and genetic stability (preferred).
• Previous experience with cell lines used in bioproduction (e.g., CHO and HEK) (preferred).
• Familiarity with cell banking, cryopreservation, cell line characterization, and the operation of bench-top stirred tank bioreactors and related process development laboratory equipment (preferred).
• Familiarity with molecular and analytical methods used to characterize recombinant cell lines (e.g., qPCR/ddPCR, flow cytometry, ELISA, or protein quantitation) (preferred).

Pay

The salary range estimated for this position based in New York is $68,000.00–$82,000.00. This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy.

Schedule

Work Schedule Standard (Mon-Fri)

Benefits

• A choice of national medical and dental plans, and a national vision plan, including health incentive programs
• Employee assistance and family support programs, including commuter benefits and tuition reimbursement
• At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
• Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
• Employees' Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount