Scientist II, Analytical Development (Oligonucleotide)

About the role

The Scientist II, Analytical Development (Oligonucleotide) position at Avidity Biosciences is a hands-on role responsible for developing and qualifying analytical methods to support oligonucleotide release and stability testing. This role requires daily lab work, data analysis, and regular reporting to cross-functional teams and key stakeholders.

Responsibilities

• Develop and qualify analytical methods (IP-RP-UPLC denaturing, non-denaturing, sequencing, identity, residual solvent, and assay content) for oligonucleotide release and stability testing.
• Work closely with external CROs to advance method development, qualification, transfer, and validation for Avidity programs.
• Provide a detailed review of protocols, reports, and raw data for analytical method qualification/validation, release testing, and reference materials qualification.
• Implement novel analytical techniques to overcome analytical challenges in the characterization of oligonucleotides.
• Document experiments in electronic notebooks and write technical reports summarizing findings.
• Author or review relevant regulatory submissions.
• Proactively present data in group and CMC meetings.
• Ensure adherence to applicable regulations, including FDA, EMA, ICH, GMP, and internal Avidity policies.
• Lead and mentor laboratory research associates.

Requirements

• Minimum PhD in chemistry, biology, biochemistry, pharmaceutical sciences, with 1-3 years of pharmaceutical industry experience or BS/MS degree with 8-10 years of industry experience.
• Deep knowledge of oligonucleotide analytical separation techniques.
• Understanding of method qualification/validation and transfer to QC. Experience in GMP or QC laboratory a plus.
• Proven track record of effective collaboration with external quality control and contract manufacturing organizations.
• Excellent communication and interpersonal skills and the ability to facilitate constructive, expedient problem-solving.
• Ability to multi-task, manage conflict, and work in a fast-paced environment.

Qualifications

• Minimum Bachelor's Degree in Chemistry, Biology, Biochemistry, Pharmaceutical Sciences, or related field.
• Experience with mass spectrometry techniques to characterize oligonucleotides (Orbitrap, QQQ, Single Quad).
• Strong knowledge of nucleic acids chemistry and oligonucleotide analytical separation techniques (IP-RP-UPLC, AEX, and HILIC).

Skills

• Strong analytical and problem-solving skills.
• Excellent communication and interpersonal skills.
• Proficiency in using laboratory equipment and software.
• Ability to work independently and collaboratively.

Benefits

• Competitive compensation and benefits package including a base salary range of $119,700 - $222,300, annual bonus, and a 401(k) with an employer match.
• Comprehensive wellness program covering medical, dental, vision, and LTD insurance.
• Four weeks of paid time off.

Pay

The base salary range for this role is $119,700 - $222,300. The final compensation will be commensurate with relevant experience, skillset, internal equity, and market factors.

Schedule

This is a full-time position.