Scientist II, Analytical Development (Oligonucleotide)

About the role

Avidity Biosciences is revolutionizing the field of RNA with its proprietary AOCs, designed to deliver a new class of RNA therapeutics. This role contributes to the development and running of oligonucleotide methods to support Avidity's AOC research and clinical programs.

Responsibilities

• Develop and qualify analytical methods for oligonucleotide release and stability testing.
• Work closely with external CROs to advance method development, qualification, transfer, and validation for Avidity programs.
• Provide a detailed review of protocols, reports, and raw data for analytical method qualification/validation, release testing, and reference materials qualification.
• Implement novel analytical techniques to overcome analytical challenges in the characterization of oligonucleotides.
• Document experiments in electronic notebooks and write technical reports summarizing findings.
• Authors or reviews relevant regulatory submissions.
• Provide updates and present data proactively and regularly in group and CMC meetings.
• Ensure adherence to applicable regulations, including FDA, EMA, ICH, GMP, and internal Avidity policies.
• Contribute to the company's core values (agile, visionary, integrated, and diverse).

Requirements

• Minimum PhD in chemistry, biology, biochemistry, pharmaceutical sciences, with 1-3 years of pharmaceutical industry experience or BS/MS degree with 8-10 years of industry experience.
• Deep knowledge of oligonucleotide analytical separation techniques.
• Understanding of method qualification/validation and transfer to QC.
• Experience in GMP or QC laboratory a plus.
• Proven track record of effective collaboration with external quality control and contract manufacturing organizations.
• Proven ability to thrive and enable success in a cross-functional and collaborative environment.
• Excellent communication and interpersonal skills and the ability to facilitate constructive, expedient problem-solving.
• Ability to multi-task, manage conflict, and work in a fast-paced environment.

Qualifications

• Strong knowledge of nucleic acids chemistry and oligonucleotide analytical separation techniques.
• Experience with mass spectrometry techniques to characterize oligonucleotides (Orbitrap, QQQ, Single Quad).

Skills

• Independent problem solver with strong attention to detail.
• Effective communicator and collaborator.
• Ability to work in a fast-paced, dynamic environment.

Benefits

To learn more about Avidity Biosciences' benefits, visit our careers page.