Scientist I/II: in vivo Pharmacology / Immuno-Oncology

Job Summary

We seek an accomplished highly motivated Scientist I/II to contribute to the development of Kernal Bio’s mRNA 2.0 platform for therapeutic applications in Boston, Massachusetts. The successful candidate will join a dynamic team of scientists and play a leading role in pre-clinically characterizing mRNA-LNP drug candidates in in vivo models.

Responsibilities

• Provide technical and scientific expertise in in vivo pharmacology to enable target identification, validation, and prioritization.
• Conduct studies in mice with primary focus on in vivo anti-tumor efficacy, PK/PD relationship, and combination strategy, biomarker identification.
• Perform standard and complex in vivo procedures including dosing all routes, tumor implant, tumor measurements and tissue necropsy.
• Ex vivo analysis of immune cells from tumor and tissues, including collection and processing of multiple samples.
• Perform routine mammalian cell culture and transfection.
• Analyze, summarize, interpret, and present experimental results to team members and management.
• Contribute to technical discussions, publications and intellectual property related to the development and application of Kernal’s proprietary technologies.
• Participate in experimental design and troubleshooting efforts.
• Maintain up-to-date electronic laboratory notebook records and communicate results to team members in written technical reports and oral presentations.
• Explore new technologies and methods to optimize current processes in a fast-paced research environment.

Requirements

• BS/MS in Biology, Pharmacology, Oncology, Immunology or equivalent experience in a related discipline.
• 4+ years of laboratory work experience in academia or industry.
• Hands on laboratory skills. In vivo skills with rodents (IV, IP, IT, SC, PO dosing), blood/tissue collection.
• Excellent in vivo study organization skills, approaching complex tasks with efficiency.
• Experience with animal models of human cancers preferred.
• Proficiency in cell transfections, ELISA, MSD, flow cytometry preferred.
• Excellent interpersonal and collaborative skills and the ability to work independently and effectively in a dynamic team environment.
• Strong written and verbal communication skills. Ability to analyze, summarize and communicate scientific data in a vivid and challenging intellectual environment.
• Excellent record keeping and data management skills.
• Adaptability and enthusiasm for new challenges, innate curiosity, and a passion for learning.
• Ability to follow novel scientific or technological developments, and to implement them in the laboratory.
• High personal and scientific integrity.

Benefits

• Competitive 401(k)
• Highly competitive healthcare coverage (PPO/HMO)
• Free parking, monthly subway pass, or a subsidized commuter rail pass
• Free Bluebike Membership
• Gym Membership Support
• Flexible Spending Account
• Paid parental leave, family caregiver leave, medical leave
• Paid life insurance coverage
• On-site cafeteria
• Competitive vacation and sick days per year