Scientist I - Brain Proteome Organization

About the role

The Allen Institute for Brain Science seeks a Scientist I to join a research team focused on understanding how the proteome of neuronal populations and their synapses shapes brain circuit function. The candidate will lead projects focused on understanding proteome organization across neuronal populations and synapse types in the brain, design and perform scalable synapse type-specific proteomics experiments, and analyze and integrate large-scale proteomic datasets with multimodal structural and functional data.

Responsibilities

• Lead projects focused on understanding proteome organization across neuronal populations and synapse types in the brain
• Design and perform scalable synapse type-specific proteomics experiments
• Develop and apply next-generation workflows for synapse isolation and proteomic analysis
• Analyze and integrate large-scale proteomic datasets with multimodal structural and functional data
• Collaborate with internal teams and core facilities to acquire and process experimental data
• Develop and improve computational and statistical strategies for data production and processing
• Maintain and manage data acquisition, storage, and deposition
• Publish and present findings in peer-reviewed journals and scientific conferences
• Execute collaborative projects within the team, across teams, and/or with external collaborators

Requirements

• Ph.D. or equivalent degree in STEM (Neuroscience, Biology, or related field)
• Proven strong publication record
• Experimental experience in lab-based research and molecular methods
• Experience in R and/or Python

Preferred

• Experience in mass spectrometry-based proteomic workflows
• Experience with large-scale biological datasets and statistical analysis
• Broad understanding of the principles of the nervous system across scales from molecules to circuits
• Ability to work independently and within a collaborative, multi-disciplinary environment
• Positive attitude, self-starter, demonstrated attention to detail, and ability to troubleshoot

Work Environment

• Exposure to and handling of laboratory animals
• Laboratory environment - possible chemical, biological, or other hazardous substances exposure
• Exposure to BioSafety Level 2 organisms, such as recombinant viruses

Position Type/Expected Hours of Work

• Occasional evening and weekend hours required
• This role is currently working onsite and is expected to work onsite for the majority of working hours. The primary work location for this role is 615 Westlake Ave N., with the flexibility to work remotely on a limited basis

Travel

• Ongoing travel to partner sites for compliance oversight required
• Attendance and participation in national and international conferences required

Additional Eligibility Qualifications

• All employees who work with live animals must complete an Occupational Health medical history form and/or consultation with an Occupational Health Provider and receive clearance to work with animals. Depending on your health history and job responsibilities, an annual respiratory health screening and clearance to use a respirator may also be required

Annualized Salary Range

$86,150 - $106,650*

*Final salary depends on the required education for the role, experience, level of skills relevant to the role, and work location, where applicable.

Benefits

Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institute's Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institute's 401k plan. Paid time off is also available as outlined in the Allen Institute's Benefits Guide. Details on the Allen Institute's benefits offering are located at the following link to the Benefits Guide: https://alleninstitute.org/careers/benefits.