Research Lab Program Manager II

About the Role

The Research Lab Program Manager II in the Department of Pediatrics Division of Hematology/Oncology will oversee the daily operations of the Barve Laboratory, which studies hematopoietic stem cell (HSC) dysfunction in Sickle Cell Disease (SCD) and other conditions, with a particular focus on senolytic and mobilization-based therapeutic strategies to restore bone marrow health. The ideal candidate will have hands-on experience with murine hematopoietic models, flow cytometry, and HSC transplantation/mobilization assays, together with laboratory management experience.

Key Responsibilities

• Conduct preclinical efficacy studies of senolytic agents (e.g., ABT-263/navitoclax) in mouse models of Sickle Cell Disease.
• Develop, adapt, and execute HSC mobilization protocols in mouse models.
• Perform and adapt single-cell characterization assays for hematopoietic stem and progenitor cells.
• Conduct flow cytometry analysis of HSPC populations, including senescence and DNA damage markers.
• Perform bone marrow and blood collections, CFU assays, and competitive/limiting-dilution transplantation studies.
• Manage the mouse colony, including breeding, genotyping oversight, and compliance with IACUC protocols.
• Provide technical training and support to postdoctoral fellows, graduate students, and research staff.
• Oversee laboratory operations, including inventory, ordering, equipment maintenance, and workflow optimization.
• Assist with data compilation, organization, and preliminary analysis for grant reporting and publications.
• Maintain QA/QC standards for laboratory assays and procedures.
• Ensure compliance with laboratory safety protocols and institutional regulatory requirements.

Minimum Requirements

• Bachelor's degree in Science or a related field and six (6) years of relevant experience or an equivalent combination of education and experience.

Preferred Qualifications

• Sample preparation techniques.
• Strong background in research coordination and management.

Competencies

• Experimental execution, performance, and data collection.
• Research Protocol Scientific Terminology.
• Flexible – ability to change directions as needed for the benefit of laboratory.
• Performance Excellence – high responsibility, pleasant to work with, provides timely and accurate information.
• Organized – manages time effectively, keeps tasks appropriately prioritized.
• Critical Thinking – ability to think through issues and identify appropriate options.
• Work Ethic – motivated, diligent, industrious and persistent in the workplace, stays on tasks to completion, works at a fast pace to ensure optimal efficiency.
• Interpersonal – can build effective, strong working relationships with colleagues and management through trust, communication, and credibility.
• Teamwork – ability to work with others, serve others, help others, take directions from others in the interest of moving process and programs forward to the desired outcome.

Pay

Target Compensation Maximum: $103,067.00
Target Compensation Minimum: $68,711.00