Research Associate / Senior Research Associate, In Vivo Pharmacology

PharmaEssentia Innovation Research Center (PIRC) is expanding its drug discovery organization in the Greater Boston area and is seeking a highly motivated Research Associate or Senior Research Associate with hands-on experience in rodent oncology models, in vivo pharmacology, and data analysis and presentation. The successful candidate will contribute to the execution of preclinical studies supporting discovery and translational research programs.

About PharmaEssentia & PIRC

PharmaEssentia Corporation is a global biopharmaceutical company founded in 2003, focused on developing innovative biologic therapeutics in hematology, oncology, and immunology. With a commercial-stage product and an expanding pipeline, PharmaEssentia integrates scientific excellence with innovative technologies to address diseases with significant unmet medical need.

Established in 2023, the PharmaEssentia Innovation Research Center (PIRC) is dedicated to advancing next-generation therapeutics through translational science, protein engineering, and novel therapeutic modalities. PIRC leverages deep expertise in oncology and immunology to identify and develop transformative therapeutic opportunities.

Responsibilities

• Execute in vivo pharmacology studies using mouse oncology models, including tumor implantation, compound administration, blood collection, and tissue harvest.
• Perform multiple dosing routes including intravenous (IV), intraperitoneal (IP), and subcutaneous (SC) administration.
• Conduct immunological assays including ELISA, MSD, and flow cytometry to characterize pharmacodynamic and immune responses following treatment.
• Culture and maintain human and murine cell lines to support xenograft, syngeneic, and in vitro pharmacology studies.
• Analyze, interpret, and present experimental data to project teams and contribute to study reports and scientific presentations.
• Maintain accurate laboratory notebooks and electronic records in compliance with institutional policies and study documentation requirements.
• Follow all IACUC protocols, SOPs, institutional policies, and applicable animal welfare regulations.
• Assist with laboratory organization, inventory management, and equipment maintenance.
• Collaborate effectively with scientists across pharmacology, translational biology, and project teams.
• Contribute to optimization of experimental procedures and implementation of new in vivo techniques.
• Senior Research Associates are expected to independently plan experimental execution, troubleshoot technical challenges, and mentor junior laboratory personnel.

Qualifications

• Bachelor's degree in Biology, Immunology, Pharmacology, Animal Science, or a related life science discipline required. Master's degree with relevant laboratory experience is preferred for Senior Research Associate candidates.
• Research Associate: 1-3 years of relevant laboratory experience in academia or industry.
• Senior Research Associate: 3-5 years of relevant experience with demonstrated independence in experimental execution and data interpretation.
• Demonstrated experience performing mouse handling, dosing, blood collection, and tissue collection.
• Experience maintaining mammalian cell cultures.
• Experience with GraphPad Prism, FlowJo, or equivalent data analysis software.
• Strong organizational and record-keeping skills.
• Ability to work independently while collaborating within multidisciplinary teams.
• Excellent written and verbal communication skills.