Postdoctoral Fellow - Neurology Research

Headquartered in Carlsbad, California, with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been discovering medical breakthroughs for more than three decades. We’re pioneers in RNA-targeted medicines, revolutionizing drug discovery and transforming lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology, and other high-need areas, we drive innovation in RNA therapies and advance new approaches in gene editing.

At Ionis, we cultivate a challenging, motivating, and rewarding environment that fosters innovation and scientific excellence. We invest in our onsite, hybrid, and remote work environments to build lasting relationships and help our culture and employees thrive. If you’re passionate about making a meaningful impact on patients in need, we invite you to join us and contribute to our unique culture while developing your career.

About the role

We are seeking a highly motivated and exceptional scientist to join our Neurology Research group as a Postdoctoral Fellow investigating the cellular and molecular mechanisms underlying white matter injury and repair. The successful candidate will develop and apply innovative cellular and animal models to identify and validate therapeutic targets that promote oligodendrocyte maturation and remyelination. This position offers an opportunity to conduct innovative research in a multidisciplinary RNA therapeutics environment and contribute to the development of novel therapies for neurological disorders.

Work location: Onsite in Carlsbad, California.

Responsibilities

• Design and execute innovative research to investigate mechanisms underlying white matter injury and repair.
• Develop and apply cellular and animal models to study disease biology and evaluate therapeutic hypotheses.
• Employ molecular, cellular, imaging, and OMICS approaches to identify and validate novel therapeutic targets.
• Analyze, interpret, and communicate experimental findings to multidisciplinary project teams.
• Publish research in peer-reviewed journals and present findings at internal and external scientific meetings.

Requirements

• Ph.D. in Neurobiology, Cell Biology, or a related discipline with a strong publication record in peer-reviewed journals.
• Research experience in oligodendrocyte biology, myelination, developmental neuroscience, or related neurobiology is highly desirable.
• Experience with human iPSC culture and differentiation, primary neural cell cultures, or advanced in vitro models is preferred.
• Experience with transcriptomic and translational profiling, single-cell RNA sequencing, or other OMICS approaches is advantageous.
• Experience with molecular biology techniques including qPCR, RNA analysis, immunocytochemistry/immunohistochemistry, and fluorescence/confocal microscopy is advantageous.
• Experience with rodent models, tissue processing, and histological analyses is beneficial.
• Strong organizational, communication, and problem-solving skills with the ability to work independently and collaboratively in a multidisciplinary environment.

Benefits

Ionis offers an excellent benefits package. Learn more about our benefits.

Pay

The pay scale for this position is $65,000 to $87,000 per year.