Postdoctoral Fellow-MSH-32076-169

Responsibilities

The Brody Laboratory is seeking highly motivated postdocs to lead projects aimed at Improving the Anti-Tumor Immune Response Induced by in situ vaccination. Goals/Outcomes of the Research Project: the current phase of this longstanding Project is to potentiate tumoral recruitment of professional Antigen Presenting Cells, particularly type 1 Dendritic Cells (DC1) and assess the impacts on presentation and cross-presentation of surrogate and neo-epitope tumor antigens to tumor-reactive T cells as well as their subsequent priming and induction of systemic anti-tumor immune response. Recent advances in the development and understanding of mRNA-lipid nanoparticles has facilitated our preliminary data showing that specific DC-recruiting chemokines can be mRNA-encoded and produced by tumors in vitro and in vivo to increase DC1-migration.

Technical Duties:

• Perform independent research in the area of cancer immunotherapy and molecular biology, to develop in silico, in vitro, and in vivo data and models to assess the impact of chemokine-mRNA-LNP therapy on DC1 recruitment and induction of in situ vaccinal anti-tumor effects.
• Critically analyze data quality and results, communicate results to scientists and lay people.
• Write or assist in writing scientific papers and grants.
• Collaborate closely with other scientists to conduct research.

Qualifications

Ph.D. required
Experience working in a research laboratory setting

Department

866 – Department of Immunology and Immunotherapy

Location

Hess – 1470 Madison Ave., 5th Fl., New York, NY 10029

Department Website

https://icahn.mssm.edu/about/departments-offices/immunology-immunotherapy

Laboratory Website

https://www.thebrodylab.org/

Qualifications

Ph.D. required
Experience working in a research laboratory setting

About the Role

This position is covered by a collective bargaining agreement between the ISMMS and the Sinai Postdoctoral Organizing Committee - UAW. Wages and benefits: See Article 5 and 13 of The collective bargaining agreement found online at https://sinaipostdocunion.org/wp-content/uploads/2023/12/12-17-23-SPOC-UAW_-Mount-Sinai-Tentative-Agreement-FINAL-PDF.pdf.

Employer Description

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual. At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally.

Compensation

The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.