Postdoctoral Fellow - Diabetes, Inflammation, Hard and Soft Tissue Healing
University of Pennsylvania Perelman School of Medicine · Erie-Meadville Area · 3 wk ago
AnalystFull-time
About the role
We are seeking an energetic Postdoctoral Fellow to join our laboratory. This role is designed for a hands-on, intellectually curious scientist who wants to take ownership of impactful projects while accelerating career growth through publication-driven science, mentorship, and leadership opportunities.
Responsibilities
- Drive projects from concept to completion by contributing to experimental design, protocol development and optimization, execution, troubleshooting, and data interpretation across integrated in vivo and in vitro platforms.
- Contribute to translational studies in genetically modified mouse models, in vivo inhibitor approaches, and immune and tissue phenotyping to define how diabetes alters inflammation and repair, including mechanistic studies of wound healing involving soft tissue or bone, innate and adaptive immune responses and key immune-cell interactions such as dendritic cells and lymphocytes.
- Apply a core toolkit spanning primary immune cell isolation and culture, functional immune assays, flow cytometry (panel design, staining optimization, acquisition, gating, and quantitative analysis), molecular and signaling assays (e.g., PCR and qPCR, pathway and protein readouts, reporter assays), and tissue-level analyses (histology, immunofluorescence or immunohistochemistry, and image-based quantification).
- Contribute to cutting-edge transcriptomic research, including next-generation sequencing workflows such as bulk RNA-seq, single-cell RNA-seq, and spatial transcriptomics, with opportunities to integrate these datasets with mechanistic wet-lab findings.
- Contribute to bioinformatics and computational analysis, including quality control, alignment and quantification, differential expression, pathway and network enrichment, cell type annotation, trajectory and cell state analyses, and multi-modal integration across transcriptomics, flow cytometry, and tissue imaging.
- Actively contribute to manuscripts and grant applications through figure generation, methods and results drafting, data synthesis, and scientific storytelling, while also developing leadership skills through mentoring and supervision of lab members and presenting findings at internal seminars and national or international conferences as projects mature.
Qualifications
- Eligibility for appointment as a postdoc requires candidates to hold, or to have completed the requirements for an advanced degree, e.g., PhD, MD, or equivalent.
- Candidates from non-U.S. universities must hold advanced degrees equivalent to those awarded in the U.S.
- Institutions must qualify for appointment as postdoctoral fellows.