Post Doctoral Research Associate - Dr. Rachid Skouta Lab

About the role

The Skouta research group covers chemical biology, and in vivo studies. The major interest of the lab is the development of small molecule inducers of ferroptosis cell death with well-defined targets for cancer therapeutics. The successful candidate will be involved in the evaluation of the efficacy study of small molecules inducing ferroptosis in mice for the development of better therapeutic treatments.

Responsibilities

• Proficiency in designing and planning in vivo studies, including dose selection, route of administration, and appropriate animal models.
• Experience in handling and caring for laboratory animals, including proper animal welfare practices, dosing techniques, and sample collection procedures.
• Understanding of toxicology study design and execution, including acute, subchronic, and chronic toxicity studies, as well as assessment of organ toxicity, immunotoxicity, genotoxicity, and carcinogenicity.
• Proficiency in analyzing biomarkers to assess the efficacy and safety of small molecules, including the use of various assays, immunoassays, and molecular techniques.
• Experience in maintaining and culturing mammalian cells, including cell line generation, transfection, and cell-based assays for assessing the effects of small molecules on cellular processes.
• Strong expertise in performing Western blot experiments, including protein gel electrophoresis, transfer, blocking, antibody incubation, detection, and quantification.
• Knowledge of protein extraction techniques from various samples, such as cells or tissues, and proficiency in protein purification methods, such as affinity chromatography or immunoprecipitation.
• Experience in monitoring studies, collecting and managing data, maintaining accurate records, and ensuring compliance with regulatory requirements.
• Strong analytical skills to analyze and interpret data generated from in vivo studies, including statistical analysis, dose-response relationships, and correlation analysis.
• Knowledge of regulatory guidelines and requirements for conducting in vivo studies, including Good Laboratory Practices (GLP) and Institutional Animal Care and Use Committee (IACUC) regulations.
• Excellent written and verbal communication skills to document and present study findings, prepare reports, and contribute to scientific publications.

Requirements

• PhD in Biology or a related field before start date of appointment.
• At least three (3) years of lab experience working with mice models is required.

Qualifications

• Highly motivated and experienced researcher with a strong background in studying the toxicity and efficacy of small molecules in vivo.

Skills

• Proficiency in designing and planning in vivo studies.
• Experience in handling and caring for laboratory animals.
• Understanding of toxicology study design and execution.
• Proficiency in analyzing biomarkers.
• Experience in maintaining and culturing mammalian cells.
• Strong expertise in performing Western blot experiments.
• Knowledge of protein extraction techniques and protein purification methods.
• Experience in monitoring studies and data management.
• Strong analytical skills for data interpretation.
• Knowledge of regulatory guidelines for in vivo studies.
• Excellent communication skills.

Benefits

N/A

Pay

Salary minimum is determined by collective bargaining agreement based on years of experience. Salary may exceed the floor and will be determined by the PI (final salary will be stated in offer letter).

Schedule

Full time position 40 hours a week, Monday - Friday, flexible hours. Some nights and weekends required.