ML Scientist I/II, Nucleic Acid Design

About the role

Lila Sciences is seeking an ML Scientist I/II, Nucleic Acid Design to advance RNA and DNA sequence design. This scientist will develop models and design strategies for understanding and engineering nucleic acid sequences, including problems such as 3’ UTR optimization, 5’ UTR optimization, CDS optimization, and promoter / enhancer design. You’ll work at the intersection of machine learning, sequence modeling, experimental design, and platform development.

Responsibilities

• Build ML models for RNA and DNA sequence design across regulatory and coding sequence contexts.
• Develop methods spanning de novo generation, sequence property prediction, diverse set selection for experimental validation, and active learning strategies.
• Deeply investigate the biological mechanisms of designed sequences and propose hypotheses about why they succeed or fail.
• Turn these insights into better models and future design principles.
• Partner with experimental scientists to propose informative assays, validation strategies, and learning loops.
• Collaborate with ML scientists and engineers across Lila to integrate nucleic acid design models into robust platforms and agent-driven frameworks.
• Stay current with research in nucleic acid biology, sequence design, and scientific ML, and share research findings externally through papers or blog posts.

Requirements

• PhD or equivalent experience in machine learning, computational biology, bioengineering, computer science, statistics, or a related quantitative field.
• Hands-on experience building, training, and evaluating ML models for DNA or RNA.
• Strong foundation in modern ML methods, with practical experience using frameworks such as PyTorch, JAX, or equivalent tools.
• Experience developing models for sequence design, sequence-function prediction, generative modeling, or active learning.
• Ability to reason about complex biological systems, scope ambiguous scientific problems, and formulate ML approaches that address difficult sequence-function challenges.
• Curiosity about nucleic acid biology, including RNA biology, regulatory genomics, or related sequence-to-function problems.
• Strong communication and collaboration skills, with a preference for team-based science and the ability to build shared technical direction across ML, engineering, platform, and experimental teams.

Qualifications

• Experience with regulatory element design, sequence-to-expression DNA models, or models trained on genomic, MPRA, STARR-seq, or related functional genomics data.
• Experience with RNA sequence-function modeling, RNA secondary structure modeling, UTR design, or inverse design methods for RNA sequences.
• Experience with sequence design in applied therapeutic contexts.
• Experience collaborating with wet-lab teams to close the design-test-learn loop, including assay design, experimental prioritization, and interpretation of validation data.
• Familiarity with high-throughput experimental datasets, pooled screens, reporter assays, or other sequence-function measurements.
• Experience translating ML research into practical biological design workflows, experimental campaigns, or platform capabilities.

Skills

• Strong judgment in applying ML to biological problems.
• Enthusiasm for areas such as regulatory genomics, RNA biology, and sequence-to-function modeling.
• Ability to work effectively in a multidisciplinary team.

Benefits

• Competitive base compensation with bonus potential and generous early-stage equity.
• U.S. Benefits: Medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company-wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office-based employees; and a company-subsidized lunch program.
• International Benefits: Comprehensive benefits program tailored to the region.

Pay

USD salary ranges apply only to U.S.-based positions; international salaries are set to local market. Expected Base Salary Range: $176,000 USD - $304,000 USD.

Schedule

Full-time position.