Scientist II, Analytical Development (Oligonucleotide)

About the role

We are seeking a Scientist II to join the Analytical Development group. This hands-on position requires daily lab work, data analysis, and interpretation of data to support our AOC research and clinical programs. The role reports to the Director of Analytical Development and is part of Avidity's growing CMC/Technical Operations team.

Responsibilities

• Apply strong knowledge of nucleic acids chemistry and oligonucleotide analytical separation techniques, including IP-RP-UPLC, AEX, and HILIC.
• Utilize mass spectrometry techniques (Orbitrap, QQQ, Single Quad) to characterize oligonucleotides.
• Independently develop and qualify analytical methods (IP-RP-UPLC denaturing, non-denaturing, sequencing, identity, residual solvent, and assay content) to support oligonucleotide release and stability testing.
• Collaborate closely with external CROs to advance method development, qualification, transfer, and validation for Avidity programs.
• Provide detailed review of protocols, reports, and raw data for analytical method qualification/validation, release testing, and reference materials qualification.
• Implement novel analytical techniques to overcome challenges in oligonucleotide characterization.
• Document experiments in electronic notebooks and write technical reports summarizing findings.
• Author or review relevant regulatory submissions.
• Provide updates and present data proactively and regularly in group and CMC meetings.
• Ensure adherence to applicable regulations, including FDA, EMA, ICH, GMP, and internal Avidity policies.
• Provide leadership and mentorship to laboratory research associates.
• Contribute to the company's core values: agile, visionary, integrated, and diverse.

Requirements

• Minimum PhD in chemistry, biology, biochemistry, or pharmaceutical sciences with 1-3 years of pharmaceutical industry experience, or BS/MS with 8-10 years of industry experience.
• Deep knowledge of oligonucleotide analytical separation techniques.
• Understanding of method qualification/validation and transfer to QC.
• Experience in GMP or QC laboratory is a plus.
• Proven track record of effective collaboration with external quality control and contract manufacturing organizations.
• Ability to thrive in a cross-functional and collaborative environment.
• Excellent communication and interpersonal skills, with the ability to facilitate constructive, expedient problem-solving.
• Ability to multi-task, manage conflict, and work in a fast-paced environment.

Benefits

• Competitive base salary range: $119,700 - $222,300.
• Opportunity for annual bonus and 401(k) with employer match.
• Comprehensive wellness program including medical, dental, vision, and long-term disability coverage.
• Four weeks of time off.

Location: Onsite, San Diego, CA. Position Type: Full Time / Exempt.