Inflammation Research - In Vivo Pharmacology Senior Scientist

About the Role

Amgen’s Department of Inflammation Research is seeking a dedicated, driven, and independent Senior Scientist to join the In Vivo Pharmacology (IVP) group. This role is part of a fast-paced, integrated, and interactive research team exploring therapeutics for Inflammation, Autoimmune, and Rare Disease programs. The successful candidate will design and execute experiments to understand drug target pharmacology, generate and communicate preclinical data, and provide technical expertise to therapeutic area scientists. This position offers the potential to manage up to one direct report, contribute to project teams, and collaborate with scientists across multiple Amgen sites.

Responsibilities

• Design, conduct, and lead in vivo preclinical model studies and ex vivo analysis independently and in collaboration with Inflammation scientists and collaborators.
• Design, execute, and analyze cutting-edge research and in vivo pharmacology experiments contributing to Amgen’s Inflammation therapeutic area pipeline.
• Manage a scientist or associate scientist-level direct report.
• Utilize in vivo pharmacology and animal models to validate and accelerate molecules through the research pipeline.
• Inform, collaborate, and communicate in vivo planning and results with therapeutic area (TA) scientists to align with project goals.
• Ensure study data quality and oversee analysis from the group.
• Represent the pharmacology team on pipeline project teams and present results at internal meetings and external conferences.

Requirements

• PhD in immunology, biology, pharmacology, or related disciplines with strong knowledge of in vivo pharmacology and PK-PD relationships. Post-doc or industry experience is a plus.
• Hands-on expertise in animal (rodent) handling and in vivo techniques (i.v., i.p., p.o., i.d., s.c., i.t., bleeds, necropsy).
• Significant experience designing and executing concurrent in vivo preclinical inflammation and autoimmune disease models. Experience with colitis, lupus, arthritis, hepatitis, and immune modulation (TLR, DTH, Immunization) models preferred. Experience in derm, rheumatoid, and respiratory disease models is also preferred.
• Hands-on experience with ex vivo/in vitro cellular and biochemical assay techniques (e.g., ELISA, MSD, WB, quantitative RT-PCR, tissue protein extraction).
• Significant experience with multicolor flow cytometry, including spectral flow approaches, and knowledge of immune cell populations.
• Experience working in a collaborative, team-oriented environment and leading in vivo contributions on project teams.
• Strong attention to detail, organizational and time management skills, accurate and timely record-keeping, and data analysis.
• Demonstrated track record of independent critical thinking and scientific achievement.
• Proficiency with GraphPad Prism, Excel, PowerPoint, and Word.

Qualifications

• Basic Qualifications:
  • Doctorate degree, or
  • Master’s degree in immunology, cell biology, or related discipline and 2 years of industry experience in biotech/pharma, or
  • Bachelor’s degree in immunology, cell biology, or related discipline and 4 years of experience in biotech/pharma.
• Preferred Qualifications:
  • Experience managing an in vivo pharmacology team or direct reports.
  • Demonstrated track record of independent critical thinking and scientific achievement, as exemplified by a publication record and/or significant contribution to a therapeutic program.
  • Proactive, curious, and eager to learn and contribute to cutting-edge science in a highly productive team environment.

Benefits

Amgen offers a Total Rewards Plan, based on eligibility, which includes:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental, and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program (or sales-based incentive plan for field sales representatives).
• Stock-based long-term incentives.
• Award-winning time-off plans.
• Flexible work models where possible.

Pay

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted on the careers site. Actual salary will vary based on relevant skills, experience, and qualifications.