Executive Medical Director (Retina Program)
for each section heading. Use - for lists. Use
for prose.
We must not repeat job title as heading. No Job ID. No application instructions. Remove cookie/navigation/legal/EEO/equal-opportunity/scam-warning boilerplate. So remove agency warnings at top, EEO statement, etc.
We need to preserve all substantive information. Let's extract content.
From posting:
- Intro: "4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery"
- "General Summary The Executive Medical Director will report to the CMO, with a dotted-line relationship to the SVP of Research & Early-Stage Product Development, and will be responsible for the design, execution, and analysis of clinical trials in the ophthalmology therapeutic area"
- "Major Duties & Responsibilities" then bullet list items (each line starts with a bold heading? Actually they are sentences with headings like "Clinical Development Leadership", "Serve as the clinical lead...". We need to treat as list items. Probably each bullet is a duty. We'll create
- for each duty.
List items:
- Clinical Development Leadership
- Serve as the clinical lead for Phase 1 retina clinical trials, including study design, protocol development, dose escalation strategy, and safety oversight
- Maintain accountability for study execution, data interpretation, and clinical readouts, including early signal detection and go/no-go recommendations
- Serve as medical monitor for assigned studies, ensuring subject safety and data integrity
- Lead cross-functional study teams (clinical operations, clinical science, biometrics, regulatory, safety, CMC, etc.) to ensure high-quality and timely trial delivery
- Provides clinical leadership to multidisciplinary study execution teams drawn from clinical operations, clinical science, biometrics, regulatory affairs, CMC, pharm/tox, drug safety, commercial, and alliance partners
- Has lead accountability on the study teams for delivery of study protocols, study conduct, and study readouts
- Biomarker & Translational Strategy
- Lead development and implementation of biomarker strategies for GA and broader retina programs
- Collaborate with research and translational teams to identify, validate, and integrate imaging, molecular, and functional biomarkers into early-phase trials
- Ensure biomarkers are aligned with mechanism of action, dose selection, and clinical endpoints to support decision-making and regulatory strategy
- Regulatory & Clinical Documentation
- Serve as the primary clinical author of development plans, protocols, IBs, INDs, CSRs, and regulatory responses
- Lead clinical contributions to IND submissions and early regulatory interactions, including Health Authority meetings for Phase 1 programs
- Ensure accuracy, scientific rigor, and regulatory compliance of all clinical documents
- External Scientific Leadership
- Organizes and leads scientific advisory board meetings. Interacts with external experts and stakeholders to gather input. Works with the research organization and the portfolio management team to identify and support new project opportunities.
- Collaborates to identify program risks, and to create and implement mitigation strategies
- Other duties as assigned
We can flatten into list items, but maybe better to keep subheadings? The instruction: use
for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). So only those specific headings? It says use for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). It seems they expect those typical headings. But we can also use other headings? It says use for section headings (e.g. ...). Likely they want us to use those headings if present. However the posting has sections like "General Summary", "Major Duties & Responsibilities", "Qualifications", "Other Qualifications/Skills", "Travel:", "Physical Requirements And Working Conditions", "Base salary compensation range". We could map them to appropriate headings: General Summary could be "About the role". Major Duties & Responsibilities -> "Responsibilities". Qualifications -> "Qualifications". Other Qualifications/Skills -> "Skills". Travel -> maybe part of "Schedule"? Not exactly. Physical Requirements And Working Conditions maybe not a standard heading; could be omitted or included as a section? The instruction: include a section ONLY when the posting has real, specific content for it — never emit a heading followed by filler/placeholder text. So we can include sections for Pay (Base salary compensation range) and maybe Schedule (Travel). Physical Requirements maybe not a standard heading; but we could include as a section with heading "Physical Requirements". However they gave examples but not exclusive. Safer to follow the posting's headings but convert to . They said use for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). That suggests we should use those headings if applicable. But we can also use other headings if they exist? The instruction ambiguous. Usually they want to standardize to those headings. Let's map:
- About the role: General Summary
- Responsibilities: Major Duties & Responsibilities
- Qualifications: Education, Experience (maybe combine)
- Skills: Other Qualifications/Skills
- Pay: Base salary compensation range
- Schedule: Travel (up to 20%)
- Benefits: not present, so omit.
- Requirements: maybe not needed separate.
We could also include "Physical Requirements And Working Conditions" as a section maybe under "Requirements"? Not sure.
Better to follow the posting's headings exactly but wrap them in . The instruction says use for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). It doesn't forbid other headings, but gives examples. I think we should use those standard headings where possible, and for any other specific content we can still use with the heading from posting. Let's do that: use for each section heading we include: "About the role", "Responsibilities", "Qualifications", "Skills", "Travel", "Physical Requirements", "Pay". That covers all.
Now we need to ensure we don't include boilerplate: agency warnings, EEO, etc. Also remove duplicated lines.
Let's craft HTML.
Structure:
About the role
4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery.
The Executive Medical Director will report to the CMO, with a dotted-line relationship to the SVP of Research & Early-Stage Product Development, and will be responsible for the design, execution, and analysis of clinical trials in the ophthalmology therapeutic area.
Responsibilities
- Serve as the clinical lead for Phase 1 retina clinical trials, including study design, protocol development, dose escalation strategy, and safety oversight
- Maintain accountability for study execution, data interpretation, and clinical readouts, including early signal detection and go/no-go recommendations
- Serve as medical monitor for assigned studies, ensuring subject safety and data integrity
- Lead cross-functional study teams (clinical operations, clinical science, biometrics, regulatory, safety, CMC, etc.) to ensure high-quality and timely trial delivery
- Provides clinical leadership to multidisciplinary study execution teams drawn from clinical operations, clinical science, biometrics, regulatory affairs, CMC, pharm/tox, drug safety, commercial, and alliance partners
- Has lead accountability on the study teams for delivery of study protocols, study conduct, and study readouts
- Lead development and implementation of biomarker strategies for GA and broader retina programs
- Collaborate with research and translational teams to identify, validate, and integrate imaging, molecular, and functional biomarkers into early-phase trials
- Ensure biomarkers are aligned with mechanism of action, dose selection, and clinical endpoints to support decision-making and regulatory strategy
- Serve as the primary clinical author of development plans, protocols, IBs, INDs, CSRs, and regulatory responses
- Lead clinical contributions to IND submissions and early regulatory interactions, including Health Authority meetings for Phase 1 programs
- Ensure accuracy, scientific rigor, and regulatory compliance of all clinical documents
- Organizes and leads scientific advisory board meetings. Interacts with external experts and stakeholders to gather input. Works with the research organization and the portfolio management team to identify and support new project opportunities.
- Collaborates to identify program risks, and to create and implement mitigation strategies
- Other duties as assigned
Qualifications
- Education: Medical Degree (M.D.), other degrees considered with relevant experience
- Residency training in Ophthalmology with a preference for subspecialty training in retina
- Board certification/retina fellowship training are a plus
- Experience: 10+ years of clinical ophthalmology research in the biopharmaceutical industry
- Experience with medical monitoring and oversight of Phase 1 retina clinical trials
- Experience with gene therapy clinical studies
- Experience in other phases (Phase 2, 3) of clinical research
- Experience with NDA/BLA/MAA submission planning and execution
- Experience in data analysis, data interpretation, and medical writing
Skills
- Knowledge of ICH-GCP and FDA regulatory guidelines
- Knowledge of international regulatory guidelines
- Effective written and verbal communication skills, including public speaking
Travel
Travel: up to 20%
Physical Requirements
Physical Activity - Repetitive motions: Making substantial movements (motions) of the
for prose. We must not repeat job title as heading. No Job ID. No application instructions. Remove cookie/navigation/legal/EEO/equal-opportunity/scam-warning boilerplate. So remove agency warnings at top, EEO statement, etc. We need to preserve all substantive information. Let's extract content. From posting: - Intro: "4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery" - "General Summary The Executive Medical Director will report to the CMO, with a dotted-line relationship to the SVP of Research & Early-Stage Product Development, and will be responsible for the design, execution, and analysis of clinical trials in the ophthalmology therapeutic area" - "Major Duties & Responsibilities" then bullet list items (each line starts with a bold heading? Actually they are sentences with headings like "Clinical Development Leadership", "Serve as the clinical lead...". We need to treat as list items. Probably each bullet is a duty. We'll create
- for each duty.
List items:
- Clinical Development Leadership
- Serve as the clinical lead for Phase 1 retina clinical trials, including study design, protocol development, dose escalation strategy, and safety oversight
- Maintain accountability for study execution, data interpretation, and clinical readouts, including early signal detection and go/no-go recommendations
- Serve as medical monitor for assigned studies, ensuring subject safety and data integrity
- Lead cross-functional study teams (clinical operations, clinical science, biometrics, regulatory, safety, CMC, etc.) to ensure high-quality and timely trial delivery
- Provides clinical leadership to multidisciplinary study execution teams drawn from clinical operations, clinical science, biometrics, regulatory affairs, CMC, pharm/tox, drug safety, commercial, and alliance partners
- Has lead accountability on the study teams for delivery of study protocols, study conduct, and study readouts
- Biomarker & Translational Strategy
- Lead development and implementation of biomarker strategies for GA and broader retina programs
- Collaborate with research and translational teams to identify, validate, and integrate imaging, molecular, and functional biomarkers into early-phase trials
- Ensure biomarkers are aligned with mechanism of action, dose selection, and clinical endpoints to support decision-making and regulatory strategy
- Regulatory & Clinical Documentation
- Serve as the primary clinical author of development plans, protocols, IBs, INDs, CSRs, and regulatory responses
- Lead clinical contributions to IND submissions and early regulatory interactions, including Health Authority meetings for Phase 1 programs
- Ensure accuracy, scientific rigor, and regulatory compliance of all clinical documents
- External Scientific Leadership
- Organizes and leads scientific advisory board meetings. Interacts with external experts and stakeholders to gather input. Works with the research organization and the portfolio management team to identify and support new project opportunities.
- Collaborates to identify program risks, and to create and implement mitigation strategies
- Other duties as assigned
We can flatten into list items, but maybe better to keep subheadings? The instruction: use
for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). So only those specific headings? It says use
for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). It seems they expect those typical headings. But we can also use other headings? It says use
for section headings (e.g. ...). Likely they want us to use those headings if present. However the posting has sections like "General Summary", "Major Duties & Responsibilities", "Qualifications", "Other Qualifications/Skills", "Travel:", "Physical Requirements And Working Conditions", "Base salary compensation range". We could map them to appropriate headings: General Summary could be "About the role". Major Duties & Responsibilities -> "Responsibilities". Qualifications -> "Qualifications". Other Qualifications/Skills -> "Skills". Travel -> maybe part of "Schedule"? Not exactly. Physical Requirements And Working Conditions maybe not a standard heading; could be omitted or included as a section? The instruction: include a section ONLY when the posting has real, specific content for it — never emit a heading followed by filler/placeholder text. So we can include sections for Pay (Base salary compensation range) and maybe Schedule (Travel). Physical Requirements maybe not a standard heading; but we could include as a section with heading "Physical Requirements". However they gave examples but not exclusive. Safer to follow the posting's headings but convert to
. They said use
for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). That suggests we should use those headings if applicable. But we can also use other headings if they exist? The instruction ambiguous. Usually they want to standardize to those headings. Let's map: - About the role: General Summary - Responsibilities: Major Duties & Responsibilities - Qualifications: Education, Experience (maybe combine) - Skills: Other Qualifications/Skills - Pay: Base salary compensation range - Schedule: Travel (up to 20%) - Benefits: not present, so omit. - Requirements: maybe not needed separate. We could also include "Physical Requirements And Working Conditions" as a section maybe under "Requirements"? Not sure. Better to follow the posting's headings exactly but wrap them in
. The instruction says use
for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). It doesn't forbid other headings, but gives examples. I think we should use those standard headings where possible, and for any other specific content we can still use
with the heading from posting. Let's do that: use
for each section heading we include: "About the role", "Responsibilities", "Qualifications", "Skills", "Travel", "Physical Requirements", "Pay". That covers all. Now we need to ensure we don't include boilerplate: agency warnings, EEO, etc. Also remove duplicated lines. Let's craft HTML. Structure:
About the role
4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery.
The Executive Medical Director will report to the CMO, with a dotted-line relationship to the SVP of Research & Early-Stage Product Development, and will be responsible for the design, execution, and analysis of clinical trials in the ophthalmology therapeutic area.
Responsibilities
- Serve as the clinical lead for Phase 1 retina clinical trials, including study design, protocol development, dose escalation strategy, and safety oversight
- Maintain accountability for study execution, data interpretation, and clinical readouts, including early signal detection and go/no-go recommendations
- Serve as medical monitor for assigned studies, ensuring subject safety and data integrity
- Lead cross-functional study teams (clinical operations, clinical science, biometrics, regulatory, safety, CMC, etc.) to ensure high-quality and timely trial delivery
- Provides clinical leadership to multidisciplinary study execution teams drawn from clinical operations, clinical science, biometrics, regulatory affairs, CMC, pharm/tox, drug safety, commercial, and alliance partners
- Has lead accountability on the study teams for delivery of study protocols, study conduct, and study readouts
- Lead development and implementation of biomarker strategies for GA and broader retina programs
- Collaborate with research and translational teams to identify, validate, and integrate imaging, molecular, and functional biomarkers into early-phase trials
- Ensure biomarkers are aligned with mechanism of action, dose selection, and clinical endpoints to support decision-making and regulatory strategy
- Serve as the primary clinical author of development plans, protocols, IBs, INDs, CSRs, and regulatory responses
- Lead clinical contributions to IND submissions and early regulatory interactions, including Health Authority meetings for Phase 1 programs
- Ensure accuracy, scientific rigor, and regulatory compliance of all clinical documents
- Organizes and leads scientific advisory board meetings. Interacts with external experts and stakeholders to gather input. Works with the research organization and the portfolio management team to identify and support new project opportunities.
- Collaborates to identify program risks, and to create and implement mitigation strategies
- Other duties as assigned
Qualifications
- Education: Medical Degree (M.D.), other degrees considered with relevant experience
- Residency training in Ophthalmology with a preference for subspecialty training in retina
- Board certification/retina fellowship training are a plus
- Experience: 10+ years of clinical ophthalmology research in the biopharmaceutical industry
- Experience with medical monitoring and oversight of Phase 1 retina clinical trials
- Experience with gene therapy clinical studies
- Experience in other phases (Phase 2, 3) of clinical research
- Experience with NDA/BLA/MAA submission planning and execution
- Experience in data analysis, data interpretation, and medical writing
Skills
- Knowledge of ICH-GCP and FDA regulatory guidelines
- Knowledge of international regulatory guidelines
- Effective written and verbal communication skills, including public speaking
Travel
Travel: up to 20%
Physical Requirements
Physical Activity - Repetitive motions: Making substantial movements (motions) of the