Director, In Vivo Pharmacology - Metabolic Disease

About the role

Pioneering Medicines, within Flagship Pioneering, is dedicated to discovering and developing novel treatments for obesity and metabolic diseases. This role represents the in vivo pharmacology function on drug discovery project teams, focusing on assessing the efficacy and pharmacokinetics/pharmacodynamics (PK/PD) of various therapeutic modalities.

Responsibilities

• Support drug discovery project teams, particularly those focused on obesity and metabolic diseases
• Design and implement in vivo efficacy and PK/PD models to evaluate lead compounds, with a focus on disease-relevant endpoints and target-specific biomarkers
• Collaborate with Flagship Platform companies and external pharmaceutical partners to advance projects towards development candidates and IND-enabling studies
• Manage direct reports and oversee studies conducted at external contract research organizations (CROs) to meet program goals
• Contribute to discussions with internal project teams, external partners, and consultants to develop comprehensive in vivo strategic plans
• Work closely with other Flagship Pioneering companies to develop research strategies and evaluate new programs

Requirements

• PhD with 10 or more years of industry experience, or MS with 12+ years of industry experience in in vivo pharmacology or related disciplines
• Strong understanding of PK/PD assessments in disease models
• Experience in designing ex vivo studies to assess PD and target engagement endpoints
• Proficient experience using rodent metabolic and behavioral cage systems and metabolic phenotyping technologies
• In-depth hands-on expertise with in vivo models of obesity and metabolic diseases, with cardiovascular experience preferred
• Experience managing in vivo personnel in a dynamic and fast-paced research environment
• Experience working with standard modalities such as small molecules, antibodies, and peptides
• A collaborative mindset and willingness to work with different teams
• Experience with animal facility management, protocol writing, study reports, interactions with Institutional Animal Care and Use Committee (IACUC), and use of Laboratory Information Management Systems (LIMS)

Qualifications

• PhD with 10 or more years of industry experience, or MS with 12+ years of industry experience in in vivo pharmacology or related disciplines
• Strong understanding of PK/PD assessments in disease models
• Experience in designing ex vivo studies to assess PD and target engagement endpoints
• Proficient experience using rodent metabolic and behavioral cage systems and metabolic phenotyping technologies
• In-depth hands-on expertise with in vivo models of obesity and metabolic diseases, with cardiovascular experience preferred
• Experience managing in vivo personnel in a dynamic and fast-paced research environment
• Experience working with standard modalities such as small molecules, antibodies, and peptides
• A collaborative mindset and willingness to work with different teams
• Experience with animal facility management, protocol writing, study reports, interactions with IACUC, and use of LIMS

Skills

• Strong understanding of PK/PD assessments in disease models
• Experience in designing ex vivo studies to assess PD and target engagement endpoints
• Proficient experience using rodent metabolic and behavioral cage systems and metabolic phenotyping technologies
• In-depth hands-on expertise with in vivo models of obesity and metabolic diseases, with cardiovascular experience preferred
• Experience managing in vivo personnel in a dynamic and fast-paced research environment
• Experience working with standard modalities such as small molecules, antibodies, and peptides
• A collaborative mindset and willingness to work with different teams
• Experience with animal facility management, protocol writing, study reports, interactions with IACUC, and use of LIMS

Benefits

• Healthcare coverage
• Annual incentive program
• Retail benefits
• Broad range of other benefits

Pay

$172,000 - $236,500

Schedule

This position is on-site/hybrid in Cambridge, MA and requires hand-on experience and being in the lab.

Contact

For questions or to apply, please visit this link.