Pioneering Medicines: Director, In Vivo Pharmacology - Metabolic Disease

About the role

Pioneering Medicines, within Flagship Pioneering, is dedicated to discovering and developing novel treatments for patients leveraging Flagship’s innovative platforms. This role represents the in vivo pharmacology function on drug discovery project teams, focusing on obesity and metabolic diseases.

Responsibilities

• Support assets in obesity and metabolic diseases on drug discovery project teams
• Identify and implement in vivo efficacy and PK/PD models to support assessment of lead small molecules, antibodies, peptides and genetic modalities, with a focus on disease-relevant endpoints, PD, and target-specific biomarkers
• Participate in partnerships and collaboration efforts with Flagship Platform companies and external pharmaceutical partners
• Collaborate closely across functions such as in vitro pharmacology, DMPK/Tox, and translational sciences to advance programs to development candidate and IND-enabling studies
• Manage direct report(s) to execute internal studies and manage studies at external CROs to achieve program goals
• This position is on-site/hybrid in Cambridge, MA and requires hand-on experience and being in the lab
• Contribute to discussions with internal project teams, external partners and consultants in developing comprehensive in vivo strategic plans
• Work closely with other FSP companies to develop research strategies and evaluate new programs

Requirements

• PhD + 10 or more years of industry experience or MS with 12+ years of industry experience within in vivo pharmacology or related discipline
• Strong understanding of PK/PD assessments in models of disease
• Experience in designing ex vivo studies to assess PD and target engagement endpoints, is a must-have
• Proficient experience using rodent metabolic and behavioral cage systems and metabolic phenotyping technologies
• In-depth hands-on expertise with in vivo models of obesity and metabolic diseases. Cardiovascular experience preferred
• Experience and managing in vivo personnel in a dynamic and fast-paced research environment preferred
• Experience working with standard modalities, such as small molecules, antibodies and peptides desired
• Collaborative mindset and a willingness to work with different teams
• Experience with animal facility management, protocol writing, study reports, interactions with IACUC, and use of LIMS

Qualifications

• PhD in Pharmacology, Physiology, Biochemistry, or related field
• 10+ years of relevant industry experience in in vivo pharmacology or related disciplines

Skills

• Expertise in in vivo pharmacology
• Strong understanding of PK/PD assessments in models of disease
• Experience with rodent metabolic and behavioral cage systems and metabolic phenotyping technologies
• Experience with in vivo models of obesity and metabolic diseases
• Experience with small molecules, antibodies, and peptides
• Excellent communication and collaboration skills
• Experience with animal facility management, protocol writing, and study reports

Benefits

Pioneering Medicines offers healthcare coverage, an annual incentive program, retirement benefits, and a broad range of other benefits.

Pay

$172,000 - $236,500

Schedule

On-site/hybrid in Cambridge, MA