Associate Director - Director, In Vivo Pharmacology

Responsibilities

• Lead in vivo pharmacology strategy for Profluent’s customized base editor programs, spanning rodent and NHP studies from early proof-of-concept through candidate nomination and IND-enabling planning. Initial programs will focus on liver-targeted therapies for inborn errors of metabolism, with opportunities to expand into extrahepatic indications over time
• Design and oversee studies evaluating editing efficiency, delivery performance, tissue biodistribution, exposure, dose response, durability, pharmacodynamic biomarkers, tolerability, and translational relevance
• Serve as the in vivo pharmacology representative on cross-functional program teams, translating complex datasets into clear recommendations for program strategy, candidate selection, dose rationale, and development path
• Lead and manage external study execution with CROs and vivarium partners, including protocol development, vivarium operations, vendor selection, study monitoring, sample logistics, data QC, troubleshooting, and report review
• Partner with bioanalytical, molecular biology, computational, and translational teams (or CROs) to integrate NGS, ddPCR/qPCR, RNA/protein, histology, clinical chemistry, cytokine, immunology, and other study readouts
• Build scalable in vivo pharmacology capabilities, including study design templates, decision criteria, CRO/vendor workflows, sample management processes, and data review standards
• Contribute to regulatory-facing pharmacology packages, including summaries of study design, dose selection, biodistribution, pharmacodynamics, durability, and translational rationale
• Mentor researchers and help establish a high-performing, collaborative, and analytically rigorous in vivo pharmacology function

Qualifications

• PhD or equivalent in pharmacology, physiology, molecular biology, genetics, bioengineering, or a related field, + 6-8 years of relevant industry experience in in vivo pharmacology and preclinical development
• Demonstrated experience designing, managing, and interpreting rodent and NHP pharmacology studies and supporting IND-enabling studies
• Experience with genetic medicines, such as genome editing, base editing, gene therapy, RNA medicines, oligonucleotide therapeutics, LNP delivery, viral vectors, or related modalities
• Strong understanding of PK/PD, dose response, biodistribution, target engagement, pharmacodynamic biomarkers, translational endpoints, and preclinical development strategy
• Experience leading CRO studies, including protocol design, vendor oversight, study monitoring, data QC, troubleshooting, and report review
• Ability to operate as a senior cross-functional scientific leader, translating in vivo data into program recommendations
• Excellent communication skills and experience presenting strategy, data, risks, and recommendations to program teams and senior leadership

What We Offer

• High-growth opportunity with meaningful impact on the future of protein design
• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace.