Associate Scientist In Vivo Pharmacology, Oncology

About the role

Join Amgens Mission of Serving Patients At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission to serve patients living with serious illnesses drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease, we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives.

Responsibilities

• Carry out hands-on in vivo work in mice, including handling, tumor inoculation and measurement, dosing (oral, SC, IP, and IV), blood and tissue collection, and health monitoring.
• Perform necropsies and support ex vivo tissue activities, including dissection, processing, sample preparation, and experimental readouts.
• Perform in vitro work including multiparametric flow cytometry and molecular biology techniques associated with in vivo studies.
• Strong communication to support study execution, maintain accurate study records, and present results.
• Active participation and presentation at cross-departmental teams and meetings.
• Participate in dosing rotations, including occasional evening or weekend work.

Qualifications

• Masters degree and 2+ years of experience in in-vivo work with rodents OR Bachelors degree and 4+ years of experience in in-vivo work with rodents OR High school diploma/GED and 6 years of experience in in-vivo work with rodents.
• Preferred qualifications include:
• M.S. degree in Oncology, Biology, or related disciplines, or B.S. degree with commensurate scientific/drug discovery experience and track record of scientific excellence and productivity.
• Hands-on experience with in-vivo models of cancer in an academic or industry setting and experience in pharmacology.
• Proficiency in various mouse techniques such as dosing, in vivo PK/PD/Efficacy, health monitoring, blood and tissue collection, preferably for small molecule oncology therapeutics.
• Experience with PDX models of cancer.
• Hands-on experience with in vivo bioluminescence imaging (BLI).
• Flow cytometry and multi-parametric analysis experience is strongly desired.
• Hands-on experience with molecular, cellular, and ex vivo biological techniques and assays.
• Computer literacy and proficiency with GraphPad Prism, Excel, PowerPoint, Word and scientific software.
• Attention to detail, excellent organizational and communication skills, accurate & timely record keeping and data analysis.
• Pro-active, enthusiastic, show desire to learn and be part of a highly productive team.