Associate Principal Scientist, In Vivo Pharmacology, Oncology

About the role

Our Discovery Quantitative Biosciences (QB) In Vivo Pharmacology – Oncology team in Boston is searching for a collaborative and innovative Associate Principal Scientist with a strong background in Oncology In Vivo Pharmacology. The successful candidate will be an experienced In Vivo cancer biologist who will direct Oncology reverse-translational activities while serving as a key intellectual contributor in the conception and execution of Oncology drug discovery projects. The role involves building alliances with Discovery Oncology teams at the Boston and South San Francisco sites, championing new technologies, and interfacing with our global pharmacology network. The successful applicant will collaborate with teams in different functional areas (e.g., Bioinformatics, Discovery Chemistry, and Discovery Biologics) in a highly matrixed system and with external partners.

Responsibilities

• Perform experiments using preclinical species to support the discovery and clinical development of novel Oncology compounds.
• Manage external studies at CROs and academic collaborators including monitoring study execution and ensuring finalization of study reports within set timelines.
• Partner and align with our global, network-wide organizational objectives, ensuring we remain at the forefront of drug discovery.
• Foster a culture of innovation and continuous improvement within the QB/Pharmacology team, driving the development and adoption of new methodologies and technologies.
• Ensure compliance with company-established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards.

Qualifications

PhD in Oncology, Pharmacology, Biology, Pharmaceutical Sciences, Chemistry, Immunology, Biotechnology, Molecular and Cell Biology, or related STEM field with 5+ years of industry/biotech experience in Oncology drug discovery, or an MS with 7+ years of experience, or a BS with 10+ years of experience.

Skills

Required Skills

• Experience using preclinical models to evaluate the in vivo pharmacology of novel modality-agnostic oncology drugs (small molecules, antibodies, ADCs, TCEs, etc.).
• Experience managing external studies at CROs and academic collaborators, including monitoring study execution and ensuring finalization of study reports within set timelines.
• Proven managerial/supervisory experience with a track record of training, developing talent, and mentoring team members in the field of Oncology/pharmacology and drug discovery.
• Proficiency in complex problem-solving and the ability to influence strategy across organizational boundaries.
• Strong skills in strategic thinking, effective communication, collaboration, balanced risk-taking, and a relentless pursuit of excellence.
• Immunoassays, Immunohistochemistry (IHC), Immunology, In Vivo Models, In Vivo Studies, Mass Spectrometry Imaging, Molecular Biology, Mouse Models, Multiplex Assays, Oncology, Pharmacodynamics, Pharmacokinetics, Pharmacology, Preclinical Research, Tumor Biology.

Preferred Skills

• Eligible for ERP (Employee Referral Program).

Pay

The salary range for this role is $144,800.00 - $227,900.00. An employee’s position within the salary range will be based on several factors including, but not limited to, relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

Benefits

We offer a comprehensive package of benefits, including:

• Medical, dental, vision healthcare, and other insurance benefits (for employee and family).
• Retirement benefits, including 401(k).
• Paid holidays, vacation, and compassionate and sick days.

More information about benefits is available at Merck Compensation and Benefits.

Schedule

• Travel Requirements: 25%