Associate Principal Scientist, In Vivo Pharmacology

We need to output HTML fragment with sections: About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. Only include sections that have real specific content. We must not repeat job title. Must not include Job ID etc. Must preserve all substantive info, remove boilerplate, navigation, legal, EEO, etc. Must not create sections with filler like "commensurate with experience". Must include Pay if posting states salary range. It does: "The salary range for this role is $159,600.00 - $251,200.00". So Pay section. Schedule: posting mentions "Must be willing to work onsite five days per week." Also "Relocation: Domestic/International VISA Sponsorship Yes Travel Requirements 10% Flexible Work Arrangements Not Applicable Shift 1st - Day". So schedule info: onsite five days per week, shift 1st - day, travel 10%, flexible work arrangements not applicable. So we can include Schedule section. Benefits: posting says "We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days." So Benefits section. Qualifications: includes Education and Required Experience And Skills. Also Preferred Experience And Skills. We can combine into Qualifications section? The instruction: Use headings for section headings like Qualifications, Skills, etc. We have both Qualifications and Skills sections. We need to decide what goes where. Typically Qualifications includes education and experience; Skills includes required and preferred skills. The posting has "Qualifications Education: ..." then "Required Experience And Skills" then "Preferred Experience And Skills". Also later "#EligibleforERP Required Skills Assay Development, ..." and "Preferred Skills Current Employees apply HERE". There's a mix. We need to extract substantive info. We should not repeat job title. Must not include boilerplate like EEO, accommodation, etc. Must not include application instructions, links, etc. Must not include "Search Firm Representatives", etc. Must not include "Employee Status Regular Relocation: Domestic/International VISA Sponsorship Yes Travel Requirements 10% Flexible Work Arrangements Not Applicable Shift 1st - Day Valid Driving License No Hazardous Material(s) N/A Job Posting End Date ..." Some of that is schedule/benefits? Travel requirements maybe schedule? We'll include travel under Schedule. We must preserve all substantive information. So we need to keep details about responsibilities, qualifications, skills, benefits, pay, schedule. We must not invent or summarize away detail. Must preserve all specifics. Thus we need to extract bullet points from responsibilities and qualifications etc. Let's parse the posting. Job Description paragraph: "We are recruiting an Associate Principal Scientist to join our In Vivo Pharmacology team located at our South San Francisco research laboratories. This role will focus on developing in vivo pharmacology strategy and pharmacodynamics (PD) and efficacy models for cardiometabolic, renal, and respiratory diseases, as well as establishing quantitative PK/PD relationship and preclinical proof-of-concept. Working with a team of multidisciplinary scientists, this individual will apply knowledge of translational animal models, in vivo technology platforms, and quantitative pharmacology to advance pipeline of therapeutic programs. The ideal candidate will possess deep scientific and technical expertise as well as strong leadership and communication skills to manage complex projects both internally and with external partners." That's About the role. Key Responsibilities list: - Drive in vivo pharmacology strategy: Act as a scientific leader, defining and executing in vivo model development and pharmacology strategy for preclinical programs. - Design and execute target engagement, PD, and efficacy studies, ensuring high scientific and ethical standards. - Provide expert troubleshooting for complex study design and protocols. - Leverage quantitative pharmacology and disease area expertise for project support: Apply pharmacology principle and best practices as well as relevant expertise in cardiometabolic, renal, or respiratory disorders to guide model/assay selection and development. - Lead model development & validation: Drive the development, characterization, and validation of relevant in vivo models and assays for target validation, compound profiling, and mechanism-of-action studies. - Represent QB on project teams and collaborate with adjacent functions (Biology, Med Chem, DMPK, Safety, etc.) to enable a comprehensive pharmacology strategy that supports robust assessment of target engagement, in vitro/in vivo correlation, PK/PD relationship, and human dose projection. - Data analysis, interpretation, and reporting: Perform rigorous quantitative data analysis, interpret key findings, and translate complex results into actionable insights that inform on project decisions. - Effectively communicate complex scientific, technical, and business information to audiences (project teams, governance bodies, external partners, etc.). - Maintain experimental documentation and contribute to internal reports, governance discussions, regulatory submissions, and publications. - CRO and external partner management: Work effectively with internal stakeholders and external partners on the design and execution of studies, ensuring data quality and timely delivery of results. Qualifications: Education: Bachelor's (with 12+ years), Master's (with 8+ years) or Ph.D./PharmD/DVM/MD (with 4+ years) in Pharmacology or a related scientific discipline and relevant drug discovery experience. Required Experience And Skills: - Quantitative and translational pharmacology expertise with a solid understanding of key pharmacology principles and concepts including target occupancy, in vitro/in vivo correlation, PK/PD, translational biomarker, and methods for human dose projection. - Proven record of success in driving in vivo pharmacology strategy and model/assay development. - Strong expertise in cardiometabolic, renal, or respiratory models and a wide range of in vivo methodologies (physiological, surgical, etc.). - Highly skilled in the design and execution of animal studies to evaluate target engagement, PK/PD, efficacy and safety profiles of drug candidates, with a range of in vivo and ex vivo techniques. - Exceptional critical thinking and organizational skills and attention to details, with a proven ability to manage complex preclinical projects in a matrix environment. - Strong teamwork and stakeholder management skills with a track record of building productive cross-functional partnerships and influencing without direct authority. - Excellent written, verbal, and presentation communication skills, with the ability to effectively communicate complex scientific, technical, and business information to audiences, including senior leadership. - Strong work ethic and flexibility, able to respond quickly to shifting priorities and multitasking needs. - Must be willing to work onsite five days per week. Preferred Experience And Skills: - Experience as pharmacology lead or representative on cross-functional project teams. - Experience with in vivo imaging techniques (ultrasound, MRI, optical imaging, etc.). - Prior experience working with multiple therapeutic modalities (small molecule, peptide, biologic, etc.). Then "#EligibleforERP Required Skills Assay Development, Cardiometabolic, Drug Discovery Research, Drug Research, In Vivo Models, In Vivo Pharmacology, Model Development, Pharmacology, Program Leadership, Renal Medicine, Respiratory Pharmacology, Strategic Thinking, Translational Pharmacokinetics and Pharmacodynamics (PKPD)". That's a list of skills. Preferred Skills: "Current Employees apply HERE Current Contingent Workers apply HERE". That's not skill. Actually after that there is "US And Puerto Rico Residents Only". Then EEO etc. Then later "The salary range for this role is $159,600.00 - $251,200.00". Then benefits description. Then application instructions etc. Then "San Francisco Residents Only: ..." etc. Then "Search Firm Representatives Please Read Carefully ..." etc. Then "Employee Status Regular Relocation: Domestic/International VISA Sponsorship Yes Travel Requirements 10% Flexible Work Arrangements Not Applicable Shift 1st - Day Valid Driving License No Hazardous Material(s) N/A Job Posting End Date 10/31/2026". Also note about posting effective date. We need to keep substantive info: Relocation, Visa sponsorship, travel requirements, shift, etc. Those could go under Schedule or maybe a separate section but we only have allowed headings: About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. So we can put relocation, visa, travel, shift under Schedule. We must not include boilerplate like EEO, accommodation, equal opportunity, etc. Also must not include "Search Firm Representatives", etc. Also must not include application instructions links, etc. Also must not include "Job Posting End Date" maybe considered metadata but could be dropped? The instruction: "do NOT put Job ID / requisition numbers as headings — fold minor metadata into a short

or drop it." So we can drop Job Posting End Date, Requisition ID, etc. Also drop "Employee Status Regular". But we might keep relocation, visa sponsorship, travel requirements, shift as schedule info. We must not include "Must be willing to work onsite five days per week." That's schedule. We must not include "Flexible Work Arrangements Not Applicable". That's schedule. We must not include "Valid Driving License No Hazardous Material(s) N/A". That's not schedule but maybe irrelevant; we can drop as minor metadata. We must preserve all substantive information: So we need to keep relocation, visa sponsorship, travel requirements, shift. Now we need to output HTML fragment with sections. We need to decide what goes into each section. About the role: The introductory paragraph(s) before Key Responsibilities. Responsibilities: The bullet list under Key Responsibilities. Requirements: Might be used for "Requirements" heading. The posting has "Qualifications" and then "Required Experience And Skills" and "Preferred Experience And Skills". Also there is a separate "Requirements" heading later? Actually after benefits there is "Requirements As an Equal Employment Opportunity Employer..." but that's EEO boilerplate, we drop. So we can treat the Qualifications and Required/Preferred as Qualifications and Skills sections. Thus: - About the role: intro paragraph. - Responsibilities: list of responsibilities. - Qualifications: Education bullet (maybe as a paragraph) plus maybe "Required Experience And Skills" could go under Skills? But we have separate Skills heading. The instruction says use headings for section headings like Qualifications, Skills, etc. So we can put education under Qualifications, and the required and preferred skills under Skills. But we also have "Required Experience And Skills" which includes both experience and skills. Could split: experience under Qualifications, skills under Skills. However the posting lumps them. To preserve all detail, we could keep them under Qualifications as a combined list of required experience and skills, and then under Skills we put the "#EligibleforERP Required Skills" list and maybe also the preferred skills list? But we also have Preferred Experience And Skills. Might be better to put all experience (education, required experience, preferred experience) under Qualifications, and all skills (required skills, preferred skills, and the list from #EligibleforERP) under Skills. Let's do that. Qualifications section content: - Education: Bachelor's (with 12+ years), Master's (with 8+ years) or Ph.D./PharmD/DVM/MD (with 4+ years) in Pharmacology or a related scientific discipline and relevant drug discovery experience. - Required Experience: Proven record of success in driving in vivo pharmacology strategy and model/assay development. Strong expertise in cardiometabolic, renal, or respiratory models and a wide range of in vivo methodologies (physiological, surgical, etc.). Highly skilled in the design and execution of animal studies to evaluate target engagement, PK/PD, efficacy and safety profiles of drug candidates, with a range of in vivo and ex vivo techniques. Exceptional critical thinking and organizational skills and attention to details, with a proven ability to manage complex preclinical projects in a matrix environment. Strong teamwork and stakeholder management skills with a track record of building productive cross-functional partnerships and influencing without direct authority. Excellent written, verbal, and presentation communication skills, with the ability to effectively communicate complex scientific, technical, and business information to audiences, including senior leadership. Strong work ethic and flexibility, able to respond quickly to shifting priorities and multitasking needs. Must be willing to work onsite five days per week. - Preferred Experience: Experience as pharmacology lead or