Associate Scientist, In Vitro Pharmacology

About the role

We are seeking a highly motivated Associate Scientist for in vitro screening and pre-clinical development to join our dynamic and fast-paced team. In this role, you will support execution of in vitro functional cell-based assays to evaluate the potency, mechanism of action, and pharmacological properties of biologic therapeutics. This role requires exceptional organizational skills, a commitment to scientific excellence, and the ability to adapt to a dynamic environment. You will report to the Associate Director, In Vitro Pharmacology and will work collaboratively in a matrixed environment to drive biologics discovery while supporting rapid decision-making in a fast-moving biotech setting.

Responsibilities

• Execute: Perform in vitro characterization and functional assays to screen drug candidate molecules.
• Develop: Optimize experimental workflows for more efficient and effective data generation.
• Deliver: Support screening campaigns to meet experimental timelines for monoclonal and multispecific antibodies, as well as TCR-mimic antibodies.
• Collaborate: Work closely across multi-disciplinary teams in biologics discovery programs spanning all Alloy sites. Engage with an inclusive and collaborative work environment.
• Communicate: Clearly convey scientific concepts, experimental results, and interpretations to internal and external stakeholders.
• Design, optimize and execute cell-based assays (e.g. cell binding and/or blocking assays, functional assays, etc.) using immortalized cell lines, primary cells, and other disease-relevant cellular systems.
• Maintain cell lines in culture using aseptic techniques.
• Process human leukopaks, isolate and characterize human PBMCs.
• Support day-to-day lab and experimental workflows.
• Effectively collaborate across divisional or departmental teams and with external partners to drive projects forward and obtain test materials and reagents.
• Present experimental data and findings during team and departmental meetings.
• Ensure timely and successful execution of project activities in alignment with project plans and priorities.
• Maintain detailed and accurate laboratory records in compliance with industry standards.
• Maintain laboratory organization and ensure compliance with safety protocols.

Requirements

• B.S. and M.S. in Cell or Molecular Biology, or a related field, with 2-4 years of relevant industry experience.
• A strong understanding of immunology and extensive hands-on laboratory experience are essential.
• Significant cell culture and flow cytometry experience required.
• Experience with antibody-based therapeutics is preferred.
• Proficient at fundamental cell and molecular biology assays (ELISA/MSD, AlphaLISA, and other methods).
• Demonstrated ability to troubleshoot, maintain, and optimize instrumentation.
• Direct experience with immune cell-based assays a plus.
• Direct experience handling human blood, leukopak processing, and PBMC isolations a plus.
• Hands on experience isolating and/or expanding primary immune cell subsets a plus.
• Excellent organization, clear communication and teamwork abilities in a multidisciplinary setting.
• Ability to effectively multitask and deliver results within project-driven timelines.
• Thrives working on a team and collaborating with others to achieve project goals.
• Enjoys a dynamic and exciting work environment.
• Detail oriented, with rigorous scientific thinking and a passion for drug discovery to improve patients’ lives.

Qualifications

• B.S. and M.S. in Cell or Molecular Biology, or a related field, with 2-4 years of relevant industry experience.

Skills

• Strong understanding of immunology and extensive hands-on laboratory experience.
• Significant cell culture and flow cytometry experience.
• Experience with antibody-based therapeutics.
• Proficient at fundamental cell and molecular biology assays (ELISA/MSD, AlphaLISA, and other methods).
• Demonstrated ability to troubleshoot, maintain, and optimize instrumentation.
• Direct experience with immune cell-based assays.
• Direct experience handling human blood, leukopak processing, and PBMC isolations.
• Hands on experience isolating and/or expanding primary immune cell subsets.
• Excellent organization, clear communication and teamwork abilities in a multidisciplinary setting.
• Ability to effectively multitask and deliver results within project-driven timelines.
• Enjoys a dynamic and exciting work environment.
• Detail oriented, with rigorous scientific thinking and a passion for drug discovery to improve patients’ lives.

Benefits

• Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered.
• Company-paid disability (STD, LTD) and life insurance.
• Paid parental leave.
• Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval).
• Annual stipend for continuing education with commitment to your career through individualized professional development plan.
• Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness.

Pay

The estimated range for this position is $94,000 - $110,000, with the final offer based on factors like your experience, skills, and alignment with our needs.

Schedule

This is an on-site and full-time position in Waltham, MA.