Associate Scientist III, Cardiac Modeling

About the role

The Opportunity insitro is a physical AI company dedicated to unlocking causal human biology and accelerating the delivery of better medicines to patients. Our unique Virtual Human™ platform identifies novel, high-impact genetic intervention points, which our TherML™ platform translates into therapeutics—whether small molecules, biologics, or oligos. With multiple programs in metabolic disease and neuroscience advancing toward the clinic, and our first IND submission slated for the second half of this year, we are at a pivotal inflection point. We are seeking an Associate Scientist III to join our cardiac disease biology team. In this role, you will support the development and application of iPSC-derived cardiomyocyte (iPSC-CM) models to study the genetic and molecular underpinnings of cardiovascular disease — working at the intersection of human stem cell biology, cardiac physiology, and scalable experimental platforms to generate the datasets that fuel our ML-driven drug discovery efforts. You will design and execute experiments, optimize differentiation workflows, develop functional and scalable functional assays to connect cellular phenotypes to disease mechanisms and therapeutic targets. Based in South San Francisco, this position reports directly to Senior Scientist, Cardiometabolic Disease - Translational Genetics and requires you to be onsite at our South San Francisco office 5 days per week.

Responsibilities

• iPSC-CM Platform & Model Development - Differentiation & QC: Support the generation and maintenance of iPSC lines and their differentiation into cardiomyocytes in 2D format (monolayers), implementing rigorous quality control points at each stage of the pipeline and with emphasis on production scalability
• iPSC-CM Platform & Model Development - Genetic Disease Models: Assist in building isogenic iPSC-CM disease models — including patient and CRISPR-edited lines carrying disease-associated variants — and characterizing the cellular model to study cardiovascular pathophysiology
• Functional Assays & Disease Modeling - Functional Readouts: Support the development and optimization of functional assays relevant to cardiovascular disease —contractility