Scientist / Senior Scientist, In Vivo Cardiac Biology

About the role

Your primary mission as an In Vivo Cardiac Biology Scientist / Senior Scientist is to drive preclinical validation of novel therapeutic targets for heart failure, including heart failure with preserved ejection fraction (HFpEF). You will lead advanced in vivo heart failure rodent studies, perform and interpret advanced physiological analyses for therapeutic efficacy, and collaborate cross-functionally to turn screening hits into high-confidence drug discovery programs.

Responsibilities

• Drive preclinical validation of novel therapeutic targets for heart failure, including HFpEF.
• Lead advanced in vivo heart failure rodent studies.
• Perform and interpret advanced physiological analyses for therapeutic efficacy.
• Collaborate cross-functionally to turn screening hits into high-confidence drug discovery programs.

Requirements

• PhD and/or postdoctoral training in cardiac biology, cardiac physiology, or a related field (or equivalent 4+ years of industry experience leading end-to-end research projects).
• Extensive hands-on experience independently running studies in rodent models of cardiovascular disease in an academic or industry setting.
• Demonstrated proficiency in rodent echocardiography (conventional short axis and auto-LV required; 4-chamber view, MV inflow, and tissue Doppler preferred) and/or invasive hemodynamics like PV loops.
• Exceptional organizational skills, attention to detail, strong written and verbal communication, a collaborative approach, and the adaptability to thrive in a fast-paced environment.
• Intrinsic alignment with target validation and drug discovery, alongside a genuine enjoyment of small animal physiology work.

Qualifications

• PhD and/or postdoctoral training in cardiac biology, cardiac physiology, or a related field (or equivalent 4+ years of industry experience leading end-to-end research projects).
• Extensive hands-on experience independently running studies in rodent models of cardiovascular disease in an academic or industry setting.
• Demonstrated proficiency in rodent echocardiography (conventional short axis and auto-LV required; 4-chamber view, MV inflow, and tissue Doppler preferred) and/or invasive hemodynamics like PV loops.
• Exceptional organizational skills, attention to detail, strong written and verbal communication, a collaborative approach, and the adaptability to thrive in a fast-paced environment.
• Intrinsic alignment with target validation and drug discovery, alongside a genuine enjoyment of small animal physiology work.

Skills

• Strong understanding of cardiovascular physiology and disease mechanisms.
• Expertise in rodent echocardiography and invasive hemodynamics.
• Ability to design, execute, and interpret complex rodent studies.
• Excellent organizational and analytical skills.
• Effective collaboration and communication skills.

Benefits

• Competitive salary range: $130,000 - $170,000 USD per year (South San Francisco).
• Full health/dental/vision/life insurance.
• 401(k) with match.
• Onsite lunch paid for 3 days a week.
• An onsite gym.
• Unlimited vacation policy.
• Remote work flexibility.
• Access to world-class mentors and advisors for professional growth.

Pay

The pay range for this role is: $130,000 - $170,000 USD per year (South San Francisco).

Schedule

Gordian doesn't follow a traditional 9 to 5 schedule. Project goals are set ambitiously, and support is provided to meet them while maintaining a balanced work-life environment.

Location

South San Francisco, CA