Senior Scientist, Cardiac Modeling
About the role
The Senior Scientist will join our cardiac disease biology team, focusing on the development and application of iPSC-derived cardiomyocyte (iPSC-CM) models to study the genetic and molecular underpinnings of cardiovascular disease. This role involves working at the intersection of human stem cell biology, cardiac physiology, and scalable experimental platforms.
Responsibilities
Ipsc-CM Platform & Model Development: Lead the generation, characterization, and maintenance of iPSC lines and their differentiation into cardiomyocytes, with rigorous quality control at each stage of the pipeline.
2D & 3D Formats: Design, implement, and optimize iPSC-CM assays in both 2D monolayer and 3D/engineered heart tissue (EHT) formats, with a focus on scalability and data quality.
Genetic Disease Models: Build and apply isogenic iPSC-CM disease models — including CRISPR-edited lines carrying disease-associated variants — to study cardiovascular pathophysiology.
Functional Assays & Disease Modeling: Develop readouts of cardiomyocyte biology relevant to disease — contractility, electrophysiology, calcium handling, stress responses — in formats compatible with high-throughput data acquisition.
Rigor & Reproducibility: Drive documentation, SOPs, and data standards that ensure reproducible, publication-quality results across the cardiac biology platform.
ML & Cross-functional Partnership: Partner with ML and computational biology teams to design experiments that generate high-quality training data and to interpret model outputs in biological context.
Target Identification: Contribute to target identification and validation efforts by connecting cellular phenotypes to human genetic evidence.
Scientific Leadership: Mentor junior scientists and technicians, and contribute to a collaborative, scientifically rigorous team culture.
Qualifications
Advanced Degree: Ph.D. in cell biology, biomedical engineering, cardiac physiology, or a related field, with at least 3 years of industry experience.
iPSC-CM Expertise: Deep hands-on experience in iPSC culture, cardiac directed differentiation, and iPSC-CM characterization across both 2D and 3D/EHT platforms.
Genetic Disease Modeling: Track record building and applying genetic iPSC-CM disease models — patient-derived lines, CRISPR-edited isogenic pairs — to study cardiovascular mechanisms.
Cardiovascular Biology: Strong foundational knowledge of cardiomyocyte biology and cardiovascular disease.
High-Content Imaging: Experience with high-content imaging and/or automated microscopy platforms, including image analysis pipelines.
Human Genetics: Familiarity with GWAS and human genetic evidence, and experience using these data to prioritize disease mechanisms or therapeutic targets.
Scientific Communication: Track record of executing rigorous experiments and communicating findings clearly in publications, presentations, or internal reports.
Core Competencies
ML Curiosity: Enthusiastic about working alongside ML scientists and understanding how experimental design shapes what a model can learn.
Builder Mentality: Thrives building systems from the ground up and brings the same rigor to a new workflow as to a published experiment.
Cross-functional Collaborator: Works fluidly across biology, computation, and chemistry, and communicates clearly across disciplines.
Independent & Adaptive: Drives projects forward independently in a fast-paced environment while staying aligned with team priorities.