Jobs · Analyst · California

Associate Scientist, Analytical Sciences

AstraZeneca · Santa Monica, CA · 2 wk ago
AnalystFull-time

About the role

Based in Santa Monica, CA, you will join a collaborative analytical operations team focused on delivering high-quality, decision-ready data for process and product characterization. Working closely with Analytical Development, Process Development, and Quality Control, you will optimize and run immunoassay and cell-based potency assays that directly influence how we develop, scale, and release next-generation cell therapies. Your work will help transform complex biology into clear evidence that advances our pipeline and ultimately benefits patients.

Responsibilities

  • Lead the setup, execution, and continuous improvement of immunoassay and cell-based testing operations, ensuring reliable turnaround times and consistent data quality.
  • Partner with method and automation developers to refine assays, increase throughput, and streamline documentation and analysis, enabling faster and more reproducible results.
  • Manage critical reagents, assay control materials, and consumables to maintain uninterrupted testing capacity and robust assay performance.
  • Thaw, culture, expand, and cryopreserve suspension/adherent cell lines; perform cytotoxicity and cytokine release assays using cell imagers, cell counters, and immunoassay kits to evaluate potency and immune effector function.
  • Coordinate and prepare engineered immune cells for co-culture and functional assays, ensuring readiness and alignment with study timelines.
  • Lead transfer of immunoassays and cell-based methods into operations by assessing incoming test methods and reagents, planning training, and securing readiness for routine use.
  • Maintain complete records for executed methods and results; monitor assay trends, identify shifts, and collaborate with developers to troubleshoot and sustain assay robustness.
  • Translate analytical outcomes into clear insights for development teams, accelerating process understanding and product characterization.
  • Provide technical mentorship to uphold scientific rigor; maintain instruments through calibration, maintenance, and troubleshooting to maximize uptime and data integrity.

Requirements

  • Two (2) years with BS/BA, or one (1) year with MS/MA in Immunology, Cell Biology, Oncology, Molecular Biology, or a related discipline with experience in a biotechnology, biopharmaceutical, or academic setting.
  • Strong expertise in cell-based assays, especially those evaluating potency or immune effector function using cell imagers and immunoassays.
  • Hands-on experience with media preparations and suspension/adherent culture work: thaw, culture, expand, and cryopreserve.
  • Proficiency in immune cell culture, including primary T cells or engineered immune cells.
  • Proficiency in data analysis and troubleshooting of cell-based analytical assays.
  • Proficient knowledge of general cell therapy processes and understanding of sampling and testing points for characterization to support process development.
  • Ability to clearly convey scientific findings and development rationale.

Desirable Skills

  • Experience in flow cytometry or genomic assays.
  • Familiarity with high-throughput assay workflows and collaboration with automation teams.
  • Experience with electronic data capture, data visualization, and assay trending tools.

Benefits

  • Qualified retirement program (401(k) plan).
  • Paid vacation and holidays.
  • Paid leaves.
  • Health benefits including medical, prescription drug, dental, and vision coverage.
  • Short-term incentive bonus opportunity.
  • Eligibility to participate in equity-based long-term incentive program (salaried roles).
  • Retirement contribution (hourly roles).

Pay

The annual base pay for this position ranges from $69,344.80 - $104,017.20 USD. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.

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