Associate Manufacturing Scientist I (2nd shift)

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a commercial-stage biopharmaceutical company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. The company focuses on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins involved in disease. Arrowhead’s RNAi-based therapeutics leverage the natural pathway of gene silencing, enabling the potential to address conditions across virtually any therapeutic area, including targets not addressable by small molecules and biologics.

About the role

This Associate Manufacturing Scientist I (second shift) role involves assisting in the synthesis and subsequent purification steps of large-scale oligonucleotides. The operator must comply with GLP/GMP protocols and follow all associated SOPs and work instructions when performing and documenting operations.

2nd shift work hours are 1:00 PM – 11:30 PM, Monday through Thursday, and include a 10% shift differential.

Responsibilities

• Follow batch records, SOPs, and work instructions to detail.
• Document all operations in batch records and logbooks.
• Comply with GMP protocols.
• Operate large-scale oligonucleotide manufacturing equipment (e.g., oligonucleotide synthesizer, purification skid, tangential flow filtration system, lyophilizer, ChemGlass reactors, pH/conductivity meters, peristaltic pumps).
• Assist other chemists within the Manufacturing group during synthesis and purification of oligonucleotides, including:
  • Reagent solution preparation
  • Mobile phase preparation
  • Column packing
  • Fraction collection
• Perform oligonucleotide/intermediate analysis via LCMS.
• Communicate with cross-functional groups such as Process Development, Analytical Development, Quality Control, and Quality Assurance.
• Maintain a clean workspace.
• Maintain safety by wearing required personal protective equipment.
• Track and update raw material usage in D365 ERP software.
• Act as production campaign lead.
• Assist with new personnel training.

Requirements

• Bachelor’s degree in Chemistry, Biochemistry, Biology, Chemical Engineering, or another scientific discipline, or equivalent relevant manufacturing experience.
• 0–2 years of laboratory or manufacturing experience in biotechnology, pharmaceutical, chemical, or related industries.
• Ability to follow detailed written procedures and maintain accurate documentation.
• Strong attention to detail and commitment to quality.
• Ability to work independently while collaborating effectively within a team.
• Strong verbal and written communication skills.
• Demonstrated ability to prioritize work in a fast-paced manufacturing environment.

Preferred Qualifications

• Experience working in a GMP-regulated manufacturing or laboratory environment.
• Hands-on experience with chromatography, filtration, purification, or analytical instrumentation such as LC-MS.
• Familiarity with manufacturing documentation, batch records, or ERP systems.

Pay

Wisconsin pay range: $60,000 USD – $70,000 USD.

Benefits

Arrowhead provides competitive salaries and an excellent benefit package.