Staff Scientist - Genomics

About the role

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

Responsibilities

• Performs next-generation sequencing library preparation and sequencing using Illumina platforms, following established standard operating procedures (SOPs).
• Conducts RNA-seq and single-cell sequencing workflows, including sample preparation, library construction, sequencing setup, and post-run quality assessment.
• Supports project intake, sample tracking, and data documentation using laboratory information management systems (LIMS) and electronic lab notebooks.
• Assists with basic downstream data quality control and interpretation in collaboration with bioinformatics staff.
• Maintains accurate records of experiments, reagents, and sequencing runs to ensure reproducibility and regulatory compliance.
• Participates in laboratory maintenance, instrument performance monitoring, and routine troubleshooting under supervision.
• Follows all biosafety, chemical safety, and data security policies and completes required HHS/NIH training.
• Collaborate closely with investigators to include but not limited to consultations, experimental design, organization, preparation of samples, and contributions to data analysis and biological interpretation. Contributes to presentations, internal reports, and publications as appropriate.
• Research, plan and engage in technology development projects to further the capabilities of the genomics group.

Requirements

• Working knowledge of Illumina sequencing platforms and NGS library preparation techniques.
• Familiarity with RNA-seq and single-cell sequencing technologies (e.g., 10x Genomics or equivalent platforms).
• Understanding of basic molecular biology techniques and experimental design.
• Ability to follow detailed protocols, maintain accurate documentation, and meet project deadlines.
• Strong organizational and communication skills to support a collaborative research environment.
• Willingness to learn new technologies and adapt to evolving research needs.

Qualifications

• Ph.D. in Genomics, Molecular Biology, Genetics, or related biological science.
• Demonstrated hands-on experience with Illumina sequencing.
• Experience or formal training in RNA-seq and/or single-cell sequencing workflows.
• Experience working in a research laboratory or core facility environment.