Genomics Sr Staff Scientist

About the role

The Genomic Senior Staff Scientist position at Stanford Health Care involves collaborating with a diverse team to provide clinical genetic and genomic test results. Key responsibilities include variant prioritization and interpretation, drafting clinical reports, and participating in quality and process improvement projects.

Responsibilities

• Evaluate the clinical relevance of genetic variants identified by clinical diagnostic tests using appropriate internal and external guidelines.
• Collect genetic, clinical, and molecular information from peer-reviewed scientific journals and public data sources.
• Critically analyze and verify the accuracy of published data and abstract information relevant to individual clinical case analyses.
• Review patient medical records and abstract information relevant to individual clinical case analyses.
• Independently classify clinically significant sequence variants (germline and/or somatic).
• Summarize results of analyses and effectively communicate results in both written and verbal formats.
• Meet interpretation turn-around times required in a clinical laboratory setting to provide prompt patient care.
• Proactively identify or volunteer to address production pressure points and take on projects to improve workplace productivity.
• Participate in the development of new clinical-grade genetic tests and/or enhancements of existing assays.
• Assist in clinical validation of new tests and workflow updates.
• Assist in the development or integration of new analysis systems, software tools, and workflows for new and existing laboratory tests.
• Identify and report errors or inconsistencies in analysis tools or online resources.
• Participate in software system verification and other quality improvement projects.
• Create verification documentation and SOP documentation drafts.
• Provide suggestions and feedback for SOP improvements of existing tests.
• Lead the implementation of productivity enhancements.
• Curate genes for new test development (Mendelian (germline) and/or oncology (somatic)).
• Contribute to preparations for audits (documentation, quality monitoring, etc.) to meet CAP/CLIA requirements.
• Create reference or training resource materials.
• Consistently adhere to C-I-CARE standards in all interactions with team members and external collaborators.
• Collaborate to resolve misunderstandings and issues early before they impact timelines, team spirit or morale.

Requirements

• PhD or MS in Molecular Biology, Genetics, or a related discipline/field, from an accredited college or university.
• Four (4) or more years of work experience in the field of genetics or cancer genetics, or combination of relevant experiences.
• One (1) year or more of work experience in a CLIA-certified clinical laboratory performing diagnostic testing.
• At least one (1) year experience must be with NGS-based tests and at least one (1) year experience in germline or cancer diagnostic testing.
• Experience in next generation sequencing and classification/curation of variants.
• Experience in databases, tools, and resources commonly used in human or model organism genetics and genomics required (e.g. ClinVar/ClinGen, gnomAD, ExAC, HGMD, COSMIC).
• Experience working in multidisciplinary team-based projects.
• Experience in variant interpretation in a clinical genetic testing laboratory required.
• Experience working both independently and on team-based projects.
• Perform day-to-day operations independently with little assistance from other team members or laboratory directors.
• Participate in clinical validation of a new test or update to existing test with minimal supervision.

Qualifications

• Education: PhD or MS in Molecular Biology, Genetics, or a related discipline/field, from an accredited college or university.
• Experience: Four (4) or more years of work experience in the field of genetics or cancer genetics, or combination of relevant experiences. One (1) year or more of work experience in a CLIA-certified clinical laboratory performing diagnostic testing. At least one (1) year experience must be with NGS-based tests and at least one (1) year experience in germline or cancer diagnostic testing.

Skills

• Experience in next generation sequencing and classification/curation of variants.
• Experience in databases, tools, and resources commonly used in human or model organism genetics and genomics required (e.g. ClinVar/ClinGen, gnomAD, ExAC, HGMD, COSMIC).
• Experience in critical evaluation of genetic data, research publications and online resources.
• Experience in databases, tools, and resources (e.g. ClinVar, gnomAD, ExAC, HGMD, COSMIC ) commonly used in human or model organism genetics and genomics required.
• Experience in variant interpretation in a clinical genetic testing laboratory required.
• Excellent communication skills (oral and written), attention to detail, problem-solving ability.
• Clear understanding of CAP requirements.

Benefits

Stanford Health Care offers competitive benefits including health insurance, retirement plans, and paid time off.

Pay

Base Pay Scale: Generally starting at $66.52 - $88.14 per hour. The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to, internal equity, experience, education, specialty and training.

Schedule

Day - 08 Hour (United States of America)