Genomics Sr Staff Scientist

About the role

This is a Stanford Health Care job. A Brief Overview As a member of the Clinical Laboratory team, the Genomic Senior Staff Scientist will collaborate with a diverse team including laboratory directors, genetic counselors, laboratory technologists, bioinformaticians, and clinicians, who work together to provide clinical genetic and genomic test results.

Responsibilities

• Evaluate the clinical relevance of genetic variants identified by clinical diagnostic tests using appropriate internal and external guidelines, including relevant evidence obtained from the scientific literature.
• Draft clinical reports.
• Contribute to quality and process improvement or development projects.
• Assist in the design, development and evaluation of new clinical-grade molecular diagnostic tests.
• Evaluate and implement evolving variant interpretation standards and workflows.
• Assist in onboarding new team members.
• Identify and report errors or inconsistencies in analysis tools or online resources.
• Participate in software system verification and other quality improvement projects.
• Create verification documentation and SOP documentation drafts.
• Provide suggestions and feedback for SOP improvements of existing tests.
• Lead the implementation of productivity enhancements.
• Curate genes for new test development (Mendelian (germline) and/or oncology (somatic)).
• Contribute to preparations for audits (documentation, quality monitoring, etc.) to meet CAP/CLIA requirements.
• Create reference or training resource materials.
• Adhere to C-I-CARE standards in all interactions with team members and external collaborators.
• Collaborate to resolve misunderstandings and issues early before they impact timelines, team spirit or morale.

Qualifications

• PhD or MS in Molecular Biology, Genetics, or a related discipline/field, from an accredited college or university.
• Four (4) or more years of work experience in the field of genetics or cancer genetics, or combination of relevant experiences.
• One (1) year or more of work experience in a CLIA-certified clinical laboratory performing diagnostic testing.
• At least one (1) year experience must be with NGS-based tests and at least one (1) year experience in germline or cancer diagnostic testing.

Skills

• Experience in next generation sequencing and classification/curation of variants.
• Ability to understand scientific literature and experimental procedures, as well as the limitations and applications of this information in a clinical setting.
• Experience in critically evaluating genetic data, research publications and online resources.
• Experience in databases, tools, and resources commonly used in human or model organism genetics and genomics required (e.g. ClinVar/ClinGen, gnomAD, ExAC, HGMD, COSMIC).
• Experience working in multidisciplinary team-based projects.
• Experience in variant interpretation in a clinical genetic testing laboratory required.
• Experience working both independently and on team-based projects.
• Perform day-to-day operations independently with little assistance from other team members or laboratory directors.
• Participate in clinical validation of a new test or update to existing test with minimal supervision.
• Create validation documentation and SOP documentation drafts requiring minimal corrections.

Benefits

Base Pay Scale: Generally starting at $66.52 - $88.14 per hour. The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to, internal equity, experience, education, specialty and training.