Staff Mechanical Engineer, Consumables

About the role

At 10x Genomics, our mission is to accelerate the mastery of biology to advance human health. We are moving with incredible urgency, and we are currently celebrating a major milestone with the unveiling of our newest innovation: Atera. This system exemplifies how we use first principles to make the impossible possible, bringing high-impact single cell analysis to more researchers than ever before. We are seeking a Staff Mechanical Engineer, Consumables who is ready to tackle the most challenging projects and help us achieve our goals.

Responsibilities

• Lead the architecture and design of complex biotech consumables, focusing on Injection Molded (IM) plastics, over-molding, LSR and assembly techniques (ultrasonic welding, laser bonding).
• Drive the development of fluidic and microfluidic systems by consulting with fluidic SMEs, ensuring seamless integration between consumable cartridges and permanent instrument hardware.
• Utilize FEA, tolerance analysis, and CFD to predict part behavior and ensure robust performance under laboratory operating conditions.
• Design for compliance with ISO 13485, FDA 21 CFR Part 820 as well as RUO. Contribute to the creation of Design History Files (DHF).
• Take full ownership of critical subsystems from "napkin sketch" through high-volume manufacturing (HVM).
• Champion Design for Manufacturing (DFM) and Design for Assembly (DFA), working closely with toolmakers and CMOs to ensure tool designs and strategies are optimized.
• Act as the primary technical point of contact for external molding partners and material suppliers, ensuring quality and performance standards are met.
• Identify and pursue patentable innovations in fluid handling, sealing technologies, and consumable-to-instrument interfaces.
• Lead complex failure analysis (FEA, SEM, etc.) for plastic components, identifying issues like creep, stress cracking, or biocompatibility failures and implementing permanent corrective actions.
• Mentor junior Engineers, fostering a culture of rigorous engineering discipline and creative problem-solving.
• Serve as the "mechanical voice" in rooms full of Biologists, Chemists, and Software Engineers to ensure the hardware meets the underlying science.

Requirements

• Education: BS/MS in Mechanical Engineering.
• Experience: 10+ years of experience in mechanical design, with at least 5 years specifically in medical devices or biotech consumables.
• Plastics Expertise: Deep knowledge of thermoplastic resins (COC, COP, PC, PP), elastomers (TPE/TPU), and the nuances of high-volume injection molding.
• Tooling/Equipment: Experience with CAD (SolidWorks/Creo), PDM systems, and simulation suites.
• Quality Systems: Familiarity with Risk Management (ISO 14971), FMEA, and Gage R&R.

Qualifications

• Strategic Design & Technical Leadership
• High-Precision Consumables
• Fluidic Integration
• Advanced Simulation
• Regulatory Excellence
• Concept to Production
• DFX Leadership
• Vendor Management
• Innovation & Problem Solving
• IP Generation
• Root Cause Analysis
• Leadership & Mentorship
• Technical Mentorship
• Cross-Functional Bridge

Skills

• Strategic Design & Technical Leadership
• High-Precision Consumables
• Fluidic Integration
• Advanced Simulation
• Regulatory Excellence
• Concept to Production
• DFX Leadership
• Vendor Management
• Innovation & Problem Solving
• IP Generation
• Root Cause Analysis
• Leadership & Mentorship
• Technical Mentorship
• Cross-Functional Bridge

Benefits

We offer a comprehensive benefits package including health and retirement programs, an annual bonus program or sales incentive program, and equity grants. Base pay ranges from $179,300 to $242,500 USD, depending on various factors.

Pay

The base pay for this full-time position ranges from $179,300 to $242,500 USD, based on individual qualifications, skills, and experience.

Schedule

This is a full-time position.

Company Overview

At 10x Genomics, we are dedicated to accelerating the mastery of biology to advance human health. We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience. We are committed to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future.