Sr. Scientist, Cell Therapy Editing Strategy and Analytics

About Astellas Astellas is a global life sciences company committed to turning innovative science into VALUE for patients. We provide transformative therapies in disease areas that include oncology, ophthalmology, urology, immunology and women's health. Through our research and development programs, we are pioneering new healthcare solutions for diseases with high unmet medical need. Learn more at Astellas.com. Are you driven to make a real difference in the lives of patients? We're seeking passionate individuals who thrive in dynamic environments, embrace new ideas, and aren't afraid to take intelligent risks. People who act with unwavering integrity and are deeply committed to making a tangible impact. Purpose & Scope The primary purpose of the Sr. Scientist, Cell Therapy Editing Strategy and Analytics role is to provide scientific expertise from the bench through planning and reporting teams, to inform editing strategies for cell therapy programs across Astellas Primary Focus indications. This position will work as part of a cross-functional team planning and executing gene-editing activities of pluripotent stem cells. This is a primarily laboratory-based role in a fast-paced environment with opportunities for bringing cutting-edge technologies to ensure efficient operation and on-time delivery of edited cells to ensure program timelines. Role And Responsibilities Design and execute complex and novel AAV-mediated gene-editing of pluripotent stem cells to develop strategies compatible with allogenic cell therapy product creation, this could extend to nuclease or recombinase-based editing systemsLead efforts to evaluate new cutting-edge gene editing technologies, develop genome engineering & hypo immune strategies; develop molecular and cellular assays for characterization of edited cellsWork cross-functionally, including on project teams to generate representative clones for downstream teamsPerform and oversee data collection, analysis and interpretation with a high degree of scientific rigorContribute to and oversee internal milestone achievements and generation of key deliverablesCommunicate results in both oral and written formats by participating regularly in team meeting preparations and presentationsLead group meeting discussions and regularly presents at cross-functional team meetings to drive decision-making and prioritiesProactively identifies challenges and proposes solutions to management in a timely manner.Prepare and review the work of others to include, but not limited to, technical slide decks, reports and Standard Operating Procedures (SOPs)Serve as a subject matter expert for tech transfer and preparation of regulatory filingsEnsure smooth day-to-day operations, including on the weekendsPerform other duties as assigned or special projects as neededStay up to date on literature and mentor junior members on product developmentMay manage a team Required Qualifications A Ph.D. in biology, genome sciences, or a related discipline with 5+ years of relevant post-graduate experience, or a MS with 8+ years, or a BS with 12+ years of highly relevant experienceSolid technical background in aseptic mammalian cell culture and process optimizationGene editing of pluripotent stem cells and associated analytical characterization assaysAbility to identify opportunities for process improvement and to problem solve in a timely manner.Strong work ethic and adaptability with a passion for working in a fast-paced, dynamic, and diverse work environmentStrong organizational and time management skills with scientific attention to detailAbility to work effectively both independently and in collaboration with other teamsExcellent communication and interpersonal skillsExcellent record keepingExperience building and managing databasesAbility to write and follow established SOPsDemonstrate and understanding of working under controlled environmentExperience managing a teamWillingness to learn new protocols, relevant equipment, and related softwareAbility to work occasional days on weekends and holidays as requiredFlexible way of working to attend early morning or late-night teleconference meetings Preferred Qualifications Experience with tech transfer to other departments and sitesStrong background in immunology and immune assaysExperience with product developmentFamiliarity with cell and gene therapy regulatory landscape Location and Working Environment This position is based in Northbrook, Illinois. Remote work from anywhere in the US is available. At Astellas we recognize the importance of work/life balance, and we are proud to offer a hybrid working solution allowing time to connect with colleagues at the office with the flexibility to also work from home. We believe this will optimize the most productive work environment for all employees to succeed and deliver. Hybrid work from certain locations may be permitted in accordance with Astellas’ Responsible Flexibility Guidelines. What awaits you at Astellas? Global collaboration: Become part of a connected global business of like-minded life science leaders, all dedicated to improving patients' lives worldwide.Real-world patient impact: Contribute to transformative therapies that reach patients around the world, knowing your work makes a difference every day.Relentless Innovation: Join a company at the forefront of scientific breakthroughs, where you'll have the opportunity to shape the future of healthcare.A Culture of Growth: Chart your own course within a supportive environment that values your contributions, champions your development, and empowers you to pursue your passions. Our Organizational Values and Behaviors Values: Innovation, Integrity and Impact sit at the heart of what we do. Behaviors: We come together as ‘One Astellas’ , working with courage and a sense of urgency . We are outcome focused and consistently take accountability for our personal contribution. Salary Range $119,000-$170,000(Final compensation will be determined based on a variety of factors, including but not limited to skills, experience and organizational equity considerations) Benefits Medical, Dental and Vision InsuranceGenerous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down401(k) match and annual company contributionCompany paid life insuranceAnnual Corporate Bonus and Quarterly Sales Incentive for eligible positionsLong Term Incentive Plan for eligible positionsCompany fleet vehicle for eligible positionsReferral bonus program \ Category Cell Therapy Analytical and Process Readiness Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans