Sr Clinical Programmer (remote)

Key Accountabilities / Core Job Responsibilities

• Lead the design, development, validation, and maintenance of SAS and R programming solutions supporting clinical study and program deliverables.
• Serve as the clinical programming lead for complex studies and programs, ensuring timely, high-quality delivery of outputs that meet regulatory and business requirements.
• Establish, maintain, and advance programming standards, reusable code libraries, and validation frameworks to improve consistency, quality, and efficiency.
• Develop innovative solutions for complex data transformations, custom listings, data integrations, and reporting requirements.
• Provide technical mentorship, code review, and subject matter expertise to programming colleagues and cross-functional partners.
• Drive adoption of CDISC standards, regulatory requirements, and industry best practices across clinical programming activities.
• Lead process improvement and automation initiatives that enhance scalability, reduce cycle times, and improve data quality.
• Partner with Clinical Data Management, Biostatistics, Clinical Operations, and external vendors to optimize data flows, study execution, and operational effectiveness.
• Author, review, and enhance standard operating procedures, work instructions, and programming documentation.
• Identify and mitigate technical, operational, and study-level risks while influencing resolution strategies across stakeholders.

Qualifications / Skills

• Typically requires a Bachelor's degree in Computer Science, Mathematics, Statistics, Life Sciences, or a related discipline; advanced degree preferred.
• Typically requires 10+ years of progressive clinical programming experience within the biotechnology, pharmaceutical, or CRO industry.
• Advanced expertise in SAS and/or R programming for clinical development and regulatory reporting.
• Demonstrated expertise in GCP, CDISC standards (including SDTM and ADaM), clinical trial data flows, and regulatory submission requirements.
• Proven ability to lead complex cross-functional initiatives and influence outcomes without direct authority.
• Experience driving programming standards, process improvements, automation initiatives, or enterprise-wide best practices.
• Strong communication, collaboration, and problem-solving skills with the ability to translate technical concepts for diverse audiences.

Pay

Salary Range: $155,000.00 to $202,000.00. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience.

Benefits

Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers.