Sr Associate Scientist, Metabolic & Muscle Diseases

About the role

We are seeking a highly motivated and experienced Sr Associate Scientist to join Obesity, Metabolism and Muscle Diseases Group. The individual will serve as a central histological resource, providing expert tissue processing and staining services to multiple Obesity, Metabolism and Muscle Diseases research programs simultaneously. The successful candidate will manage end-to-end histological workflows spanning a broad range of tissue types, maintain rigorous quality standards. This role demands both deep technical proficiency and strong interpersonal skills to navigate competing program demands and deliver high-quality data on time.

Responsibilities

• Tissue processing, including tissue fixation, dehydration, clearing, embedding, and sectioning samples from multiple tissue types (e.g., liver, heart, brain, muscle, adipose).
• Routine histological staining (e.g H&E, Sirius Red, PAS, Oil Red O) and special staining according to the program needs.
• Conduct immunohistochemistry (IHC) and immunofluorescence (IF); develop, optimize, and validate new IHC/IF protocols, antibody titrations, and antigen retrieval conditions.
• Apply in situ hybridization (ISH/RNAscope) techniques for gene expression localization where required.
• Perform image aquation, using different scanning platforms (e.g. Aperio, Zeiss Axioscan), and manage image data repositories.
• Perform quantitative image analysis using platforms such as HALO, develop and apply customized image analysis algorithms.
• Generate high-quality figures and data summaries suitable for internal reports, regulatory packages, and peer-reviewed publications.
• Maintain and communicate a dynamic workload tracker; proactively flag capacity constraints or scheduling conflicts to stakeholders.
• Adapt rapidly to shifting program priorities and animal study schedules.

Requirements

• BS with 5+ years or MS with 2+ years of relevant experience
• Proficiency in standard and special histochemical staining techniques across multiple tissue types.
• Demonstrated IHC/IF assay development, optimization, and troubleshooting experience.
• Ability to optimize processing and staining protocols for challenging tissue types or low-abundance samples.
• Proficiency with whole-slide imaging systems and digital pathology image analysis software (e.g. HALO).
• Experience with in situ hybridization platforms (RNAscope, BaseScope, FISH) is a plus.
• Strong organizational and record-keeping skills.
• Able to manage and prioritize simultaneous requests from multiple stakeholders.
• Excellent oral and written communication skills.
• Ability to present data at lab meetings.

Qualifications

• You enjoy working in a fast-paced environment.
• You are a fast learner and have a desire to expand your skill set and learn new techniques.
• You are detail oriented, well-organized, and can multi-task.
• You are a team player.
• You have strong communication skills.

Benefits

This role may be for you if:

• You enjoy working in a fast-paced environment
• You are a fast learner and have desire to expand your skill set and learn new techniques
• You are detail oriented, well-organized and can multi-task
• You are a team player
• You have strong communication skills

Pay

$80,300.00 - $131,100.00 annually

Schedule

Full time