Senior Scientist, Lentiviral Vector Cell Line Development

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We are developing a mammalian synthetic biology platform––from cells to software––to enable the design and manufacture of next-generation therapeutics. We are hiring a Senior Scientist to lead our Lentiviral Vector Cell Line Development team in Boston, MA. This role blends strategic leadership with hands-on experimentation, giving you direct influence over our Lentiviral Vector platform roadmap and scientific vision. You will drive the creation of stable producer cell lines for lentiviral vector therapeutics while innovating next-generation cell line development workflows. This is a unique opportunity to work at a nimble, forward-thinking synthetic biology startup and help build the future of biological engineering.

About The Role

• Set and steer the scientific roadmap for the Lentiviral Vector cell line development (CLD) platform.
• Perform lentiviral vector stable producer cell line development processes including transfection, pool generation, single cell cloning, clone screening and characterization, and cell banking using state-of-the-art equipment.
• Serve as the primary Lentiviral Vector CLD technical contact on customer and commercial projects.
• Partner with our commercial team to present platform capabilities to prospective partners and translate customer requirements into executable CLD project plans.
• Provide technical leadership and mentorship to scientists on the team, including managing direct report(s) and setting a high bar for experimental design, data analysis and record-keeping.
• Represent Lentiviral Vector CLD on cross-functional and leadership-facing project teams, making calls on cell line development strategy and clearly communicating progress, risk and plans.
• Support innovation through development of novel workflows and applications.
• Support research projects to develop viral vector production methods to enhance product quality attributes such as empty/full ratio, potency and/or cell targeting.
• Work effectively as part of a cross-functional team in support of a Lentiviral Vector CLD platform and in collaboration with Synthetic Biology and Process Development teams.
• Design experiments, analyze data, troubleshoot, and maintain detailed records.
• Represent Lentiviral Vector CLD on project teams, making decisions for cell line development activities and effectively communicating results, progress and plans.
• Represent Asimov's science externally through publications and presentations at leading industry conferences.

About You

• M.S. or PhD in Biological Engineering, Virology, Cell Biology, Molecular Biology, or a related field.
• 7+ years of hands-on experience in biopharma, including 4+ years focused on lentiviral vector producer or packaging cell line development in support of GLP or GMP production of cell or gene therapies.
• 2+ years of experience managing direct report(s) and providing technical guidance.
• Proven track record balancing hands-on bench leadership with big-picture platform strategy and roadmapping.
• Experience communicating technical work to external stakeholders and translating their needs into technical plans.
• Demonstrated ability to communicate scientific work externally, evidenced by publications, patents, and/or conference presentations.
• Experience with downstream purification and PQ assessment of lentiviral vectors, T-cell transduction assay, viral genome engineering, and/or host cell genome engineering related to virus production or producer cell line technologies is highly desired.
• Experience with process development at Ambr or benchtop bioreactor scale is a plus.
• Comfortable working with large, multidimensional datasets and applying statistical or computational methods to extract actionable biological or process insights.
• Strong written and verbal communication skills required.

Pay

Compensation Range: $145K - $165K