Senior Scientist - Imaging

Regeneron uses science and innovation to develop life-changing medicines for people with serious diseases. Join our Imaging team as a Senior Scientist, MRI to execute preclinical MRI studies of rodent models in collaboration with therapeutic focus areas, technology teams, and imaging scientists.

About the role

You will work with the Imaging team's Lead MRI Scientist to coordinate experimental design, plan and schedule animal imaging sessions, acquire MR images using the 7T Bruker BioSpin system, and ensure MRI data are relevant, actionable, and of high quality. These data and derived results will be communicated to Regeneron's broader scientific community. You will also collaborate to optimize and develop MRI protocols for new techniques and animal models.

Current and emerging projects include:

• Cardiac imaging of the mouse and rat heart to derive structural and functional endpoints
• Neuroanatomical volume measurements from high-resolution in vivo brain imaging to measure volumetric brain changes associated with aging and disease
• High-resolution anatomical imaging of the inner ear
• Magnetic resonance spectroscopy to measure local brain metabolite concentration in genetic models of metabolic disorders

Responsibilities

• Work closely with the lead MRI scientist to understand project needs and priorities, troubleshoot experiments, and provide updates on project progress
• Independently execute projects planned in consultation with the lead MRI scientist and in collaboration with scientists and specialists in Imaging and relevant therapeutic focus areas
• Operate and optimize the high field strength MRI for in vivo and ex vivo studies of preclinical rodent models, including critical evaluation of data acquisition
• Perform animal handling, such as administration of anesthesia, preparing animals for scanning, administration of contrast agents, animal monitoring, and preparation of tissue for ex vivo imaging
• Maintain online and physical records of data from ongoing and completed projects

Requirements

• MSc or PhD in Engineering, Biophysics, Biology, Chemistry, or a similar field
• 5+ years of experience operating in vivo rodent MRI
• 5+ years of in vivo mouse/rat handling, including anesthesia, injections, and tissue processing
• Experience with 3D MRI visualization software such as 3D Slicer, ITK Snap, or ImageJ
• Knowledge of basic MRI science and the ability to communicate it to a general audience
• Knowledge of mouse and rat anatomy, with the ability to incorporate this into MRI study design
• Exceptional critical thinking, attention to detail, scientific rigor, and strong analytical, problem-solving, and troubleshooting skills
• Ability to shift focus between multiple projects while still meeting deadlines
• Proven ability to work independently and collaboratively as part of a larger project
• Positive attitude and willingness to learn new things
• Passion for biology and helping others
• Dedication to sharing, collaborating, and lifting others up

Preferred Qualifications

• Experience with Bruker ParaVision software, MRI protocol development, cardiac/respiratory/functional gating or triggering techniques
• Experience with MRI/MRS processing software (VivoQuant, Amira, LCModel, FID-A, FSL, etc.)

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role:

• Annual bonuses or other incentive plans
• Equity awards
• Pension or retirement benefits, 401(k) company match
• Health and wellness programs, fitness centers
• Insurance benefits (e.g. medical, dental, vision, life and disability)
• Paid time off
• Family support benefits

Pay

Salary Range (annually): $109,900.00 - $179,300.00

Schedule

This role is on-site in Tarrytown, NY.