Senior Scientist I-II, Conjugation

About the role

We are seeking a highly motivated and qualified individual to join our Conjugation-Discovery Chemistry Department as a Senior Scientist I and work as part of a team to drive success. Ideal candidates will be self-motivated, independent, committed to the generation of high-quality data within a fast-paced and innovative research team.

Responsibilities

• Design, synthesis, purification and analysis of oligonucleotide-conjugates on antibodies and other modalities.
• Develop and optimize conjugation protocols using novel chemistries and technologies for target drug delivery.
• Evaluate SAR on the conjugates and drive the program by collaborating cross-functionally with the teams.
• Track progress against project timelines, generate regular status updates, and communicate progress to the team.
• Carry out assigned laboratory functions applying knowledge and skill in an accurate, timely manner.
• Establish and maintain excellent working relationships with critical collaborative partners throughout the company to advance discovery research activities to pre-clinical development.
• Contribute to the preparation of research reports and presentations for internal project teams, leadership team, and external audience.
• Manage and maintain equipment, reagents and dedicated laboratory environment needed to carry out assignments.
• Maintain updated and well-organized lab notebooks and batch records.
• Execute daily laboratory operations with an approach designed to minimize risks and hazard waste streams.

Qualifications

• Ph.D. in Chemistry, or related scientific discipline
• 3-5 years bioconjugation-related industrial experience
• Understanding of project timelines and deliverables and plans/coordinate project work accordingly with departmental, functional, and external stakeholders
• Strong problem-solving skills and a proactive attitude towards exploring new approaches
• Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management teams are essential for this role
• In-depth knowledge of modern bioconjugation methods on antibodies (ADC, AOC), proteins, peptides, and other biomolecules
• Hands-on experience in the analytical characterization of the conjugates with strong analytical mindset
• Proficiency in purification techniques such as RP-HPLC, FPLC, SEC, and IEX
• Proficiency working with Microsoft Office Suite Products

Preferred Qualifications

• Team management experience
• Previous experience with RNA/oligonucleotide therapeutics is preferred but not essential
• A track-record of impacting drug discovery programs through driving projects to key decision points
• In-depth knowledge of modern organic synthetic methods, purification and analytical techniques as well as medicinal chemistry

Key Attributes

• Positive attitude and high personal and ethical standards
• A strong team player with a passion for science and drug discovery
• Must be able to work independently as well in cross-functional team settings with supervision as needed
• Adaptable / Flexible - willing and able to adjust to multiple demands and shifting priorities as well as an ability to meet day-to-day challenges with confidence and professionalism
• Self-motivated with excellent interpersonal, organizational and communication skills with the ability to take a hands-on approach to work effectively in a dynamic and collaborative, fast-paced environment