Scientist II, Conjugation Development

Responsibilities

• Optimize and troubleshoot multi-step syntheses of protein-polysaccharide conjugates.
• Purify polysaccharides and conjugates using a variety of methods including dialysis, size-exclusion chromatography, and tangential flow filtration (TFF).
• Analyze polysaccharides and conjugates with a variety of analytical methods.
• Develop new laboratory workflows and analyses beyond established procedures when appropriate.
• Advise team members on experimental design, interpretation of results, and troubleshooting.
• Serve as a subject matter expert during tech transfer of conjugation processes to contract manufacturing organizations.
• Maintain highly organized records to enable optimization and assessment of reproducibility.
• Attend team meetings ready to provide updates on conjugation development progress.

Requirements

• PhD in chemistry, biochemistry, or related field with minimum 2-5 years of industry experience, or combination of industry and postdoctoral research; MS with minimum 7 years industry experience, or BS with minimum 10 years of industry experience.
• Strong biochemistry and organic chemistry knowledge base underpinning several years’ experience preparing bioconjugates.
• Proficiency with small- and large-scale techniques for purification of bioconjugates, including tangential flow filtration.
• Proficiency in a variety of techniques for bioconjugate analysis such as colorimetric assays, HPLC, and SEC-MALS.
• Sufficient knowledge of analytical principles to develop fit-for-purpose analytical methods as needed and provide cross-functional feedback on draft analytical methods.
• Experience with Design of Experiments is desirable.
• Experience with chemical modification of polysaccharides is desirable.
• Experience implementing and/or using electronic notebooks is desirable.
• Attention to detail and excellent organizational skills.
• Strong interpersonal skills; ability to communicate effectively both verbally and in written formats.
• Self-starter; ability to work in a fast-paced, cross-functional environment and collaborate effectively with other team members.
• Enthusiasm to learn the new skills and techniques necessary to tackle problems outside of current area of expertise.