(Senior) Scientist –High-resolution Mass Spectrometry

Key Responsibilities

• Design and develop advanced (High Resolution) Mass Spectrometry-based methods for structure elucidation of diverse active pharmaceutical ingredients.
• Take the lead/assist in the development of databases, spectral libraries and in silico tools to facilitate MS-based structure elucidation.
• Apply state-of-the-art scientific knowledge to ensure high-quality of the delivered results.
• Work in a multidisciplinary team of scientists and show the ability to learn and explore new analytical techniques.
• Maintain a safe work environment in compliance with all applicable environmental, health, regulatory requirements, GMP and safety regulations.
• Independently troubleshoot diverse mass spectrometers.
• Lead comprehensive root cause investigations related to MS-based structure elucidation of compounds within our R&D and commercial portfolio.
• Stay abreast with scientific knowledge to guarantee the delivery of high-quality results, strengthening our position as leaders in mass spectrometry-based structure elucidation.
• Initiate and lead partnerships with universities and other research institutions to expand our external innovation network, fostering collaboration that enhances our capabilities and expertise.

Qualifications

• A PhD degree in analytical chemistry or related field; or a master’s degree in related science with a minimum of 6 years of experience.
• Proven in-depth and hands-on expertise in high-resolution mass spectrometry is essential for this role, particularly with a focus on MS-based structure elucidation.
• Experience with coding, programming and the use of in silico tools to assist structure elucidation is a clear plus.
• Working experience with mass spectrometry of (cyclic) peptides, oligonucleotides and/or ADCs is an advantage.
• Hands-on experience with advanced hyphenated separation technology such as capillary electrophoresis (CE) or multidimensional liquid chromatography is an asset.
• Knowledge of regulatory frameworks (e.g., ICH, EMA, FDA) and GMP guidelines, particularly concerning validation requirements, is an advantage.
• Excellent English communication skills, both written and spoken, allowing for effective scientific discussions and collaboration.