Senior Scientist, Conjugation Process Development

About the role

Pfizer’s purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most.

Responsibilities

• Independently design, execute, and interpret studies intended to answer a defined question within the defined timeframe.
• Design subsequent experiments upon interpretation of data.
• Monitor results, identify problems, and develop solutions.
• Facilitate technology/assay transfers internally/externally.
• Regularly contribute at department and project team level and represent the group on multidisciplinary teams.
• May present at national/international forums.
• Author and review technical reports, manufacturing documents, regulatory submissions and publications.
• Identify areas for process improvement and technology development and propose solutions.

Qualifications

• Bachelor's Degree with 9 to 11 years of experience, Master's Degree with 7 to 8 years of experience, or PhD and 0-3 years of experience
• Must have a degree in chemistry, biochemistry, chemical engineering, or related field
• Direct experience with antibodies, proteins, and/or bioconjugation
• Good understanding of analytical protein characterization (HPLC, IEF, CE-SDS)
• Willingness to work with highly potent cytotoxic molecules
• Able to perform complex data analysis
• Excellent oral and written communication skills
• Foundational understanding of organic chemistry, reaction mechanisms, and process development

Nice to Have

• Experience with tangential flow filtration
• Experience using statistical and data analysis software, such as JMP, for experimental design, data visualization, and interpretation
• Experience with GMP manufacturing
• Familiarity with CMC team function
• Experience with technology transfer to manufacturing
• Familiarity with chemical synthesis, protein modification, bioconjugation chemistry, and the application of analytical technologies to process development

Other Job Details

• Work Location: On Premise
• Annual Base Salary Range: $93,600.00 to $156,000.00
• Eligible for Global Performance Plan with a bonus target of 12.5% of the base salary and participation in share-based long-term incentive program
• Comprehensive and generous benefits including 401(k) plan with Pfizer Matching Contributions, additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage