Senior Scientist: Bispecifics and Antibody Engineering
About the role
We are seeking a results-driven Senior Scientist to join Regenerons Antibody Engineering team within the Bispecifics and Antibody Engineering Department. In this fast-paced, innovative group, you will design, produce, and characterize next-generation antibody and protein therapeutics across multiple therapeutic areas with a focus on myeloid cell biology. Your work will directly contribute to the pipeline and help build new platform capabilities at a pivotal time for antibody engineering.
Responsibilities
- Apply molecular and structural biology expertise to independently design innovative multi-specific antibodies with desired potency, selectivity and developability.
- Molecular and structural-guided design, high-throughput construct generation, and vector engineering using modern software and tools.
- Produce and purify novel and logic-gated alternative format antibodies using mammalian expression systems utilizing an assortment of molecular biology & biochemical techniques (i.e. AKTA systems and other chromatographic columns).
- Characterize binding affinities, binding kinetics & stability. Design and implement high-throughput and properly controlled biochemical and cell-based assays (ELISA and AlphaLISA, flow cytometry binding, phagocytic assays, cell activation and cytolytic assays).
- Troubleshoot bioanalytical and cell-based assay data to inform subsequent iterations.
- Engage program stakeholders to communicate biologic designs with data updates to meet program objectives. Clearly convey results to management during cross-departmental meetings and maintain timely, accurate entries using Benchling and research ELN.
Requirements
Expertise in myeloid, molecular, and protein biology. Learn new skills quickly and troubleshoot antibody production and functional assays effectively. Excel in data analysis and interpretation while supporting multiple projects simultaneously. Competently prioritize efforts to quickly adapt to evolving program directions. Possess exemplary organizational, communication, and presentation skills. Enjoy collaborating across diverse, cross-functional teams.
Qualifications
- PhD in molecular biology, cell biology, biochemistry, immunology or a related field with at least one year of relevant experience in academia or industry.
- Core hands-on experience with cloning, antibody expression in mammalian cell lines, antibody purification (i.e., using AKTA systems), and comprehensive protein characterization is desired; however, we are excited to train motivated learners.
- Familiarity with cell-free expression and structural AI/ML-design is preferred but not required.
Skills
Expertise in myeloid, molecular, and protein biology. Learn new skills quickly and troubleshoot antibody production and functional assays effectively. Excel in data analysis and interpretation while supporting multiple projects simultaneously. Competently prioritize efforts to quickly adapt to evolving program directions. Possess exemplary organizational, communication, and presentation skills. Enjoy collaborating across diverse, cross-functional teams.
Benefits
Not specified
Pay
$109,900.00 - $179,300.00 annually
Schedule
Not specified